Seroatlas · Human Serome Atlas

DEFB108A

Putative beta-defensin 108A

Also known as: DB108_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MXU0
Gene: DEFB108A
Canonical length: 73 aa

OverviewNCBI Gene

No narrative summary is available for DEFB108A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

73 residues, UniProt reviewed canonical sequence.

>A8MXU0|DEFB108A
     1  MRIAVLFFTI FFFMSQVLPA KGKFKEICER PNGSCRDFCL ETEIHVGRCL NSRPCCLPLG
    61  HQPRIESTTP KKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DEFB108A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54

OntologyGO

Biological processes

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DEFB108A as an antibody target. Whether an autoantibody or antibody against DEFB108A could matter depends on whether native DEFB108A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DEFB108A is annotated as secreted, so native DEFB108A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DEFB108A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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