Seroatlas · Human Serome Atlas

DDTL

D-dopachrome decarboxylase-like protein

Also known as: DDTL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NHG4
Gene
DDTL
Ensembl
ENSG00000099974
Chromosome
22
Canonical length
134 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable phenylpyruvate tautomerase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>A6NHG4|DDTL
     1  MPFLELDTNL PANRVPAGLE KRLCAAAASI LGKPADRVNV TVRPGLAMAL SGSTEPCAQL
    61  SISSIGVVGT AEDNRSHSAH FFEFLTKELA LGQDRFPTVL STSPAAHGGP RCPGEIIEGK
   121  KSCLNEEALF IYFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDTL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • liver: 58 nTPM
  • pancreas: 15 nTPM
  • kidney: 11 nTPM
  • stomach: 9.5 nTPM
  • prostate: 8.1 nTPM
  • small intestine: 7.9 nTPM

Single-cell type

  • epicardial cells: 2.3 nCPM
  • proximal tubule cells: 1.5 nCPM
  • renal collecting duct intercalated cells: 1.4 nCPM
  • renal connecting tubule cells: 1.3 nCPM
  • loop of henle epithelial cells: 1 nCPM
  • lacrimal acinar cells: 0.9 nCPM

Immune cell

  • basophil: 1 nTPM
  • gdT-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 0.7 nTPM
  • pons: 0.7 nTPM
  • midbrain: 0.4 nTPM
  • white matter: 0.4 nTPM
  • cerebral cortex: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.84
gnomAD pLI
0.33
gnomAD missense Z
0.06

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDTL as an antibody target. Whether an autoantibody or antibody against DDTL could matter depends on whether native DDTL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDTL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDTL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DDTL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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