Seroatlas · Human Serome Atlas

DDT

D-dopachrome decarboxylase

Also known as: D-DT, DDCT, DOPD_HUMAN, MIF-2, MIF2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P30046
Gene
DDT
Ensembl
ENSG00000099977
Chromosome
22
Canonical length
118 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Mitochondria
Quaternary structure
Homotrimer

OverviewNCBI Gene

Predicted to enable phenylpyruvate tautomerase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>P30046|DDT
     1  MPFLELDTNL PANRVPAGLE KRLCAAAASI LGKPADRVNV TVRPGLAMAL SGSTEPCAQL
    61  SISSIGVVGT AEDNRSHSAH FFEFLTKELA LGQDRILIRF FPLESWQIGK IGTVMTFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
1,021 nTPM

Expression across tissuesHPA

Tissue

  • liver: 1,021 nTPM
  • pancreas: 318 nTPM
  • kidney: 273 nTPM
  • stomach: 215 nTPM
  • heart muscle: 203 nTPM
  • skeletal muscle: 159 nTPM

Single-cell type

  • hepatocytes: 3,220 nCPM
  • parietal cells: 979 nCPM
  • enterocytes: 573 nCPM
  • gastric chief cells: 458 nCPM
  • enteric transient amplifying cells: 449 nCPM
  • late spermatids: 418 nCPM

Immune cell

  • plasmacytoid DC: 286 nTPM
  • classical monocyte: 207 nTPM
  • myeloid DC: 195 nTPM
  • intermediate monocyte: 186 nTPM
  • non-classical monocyte: 176 nTPM
  • total PBMC: 174 nTPM

Brain region

  • thalamus: 87 nTPM
  • white matter: 86 nTPM
  • cerebellum: 85 nTPM
  • hypothalamus: 81 nTPM
  • medulla oblongata: 76 nTPM
  • basal ganglia: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.84
gnomAD pLI
0.33
gnomAD missense Z
-0.03

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDT as an antibody target. Whether an autoantibody or antibody against DDT could matter depends on whether native DDT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DDT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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