Seroatlas · Human Serome Atlas

DDIAS

DNA damage-induced apoptosis suppressor protein

Also known as: C11orf82, DDIAS_HUMAN, FLJ25416, FLJ38838, noxin

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXT1
Gene: DDIAS
Ensembl: ENSG00000165490
Chromosome: 11
Canonical length: 998 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage and regulation of DNA stability. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

998 residues, UniProt reviewed canonical sequence.

>Q8IXT1|DDIAS
     1  MNRRRKFLLA SVLALQNSSF IYPSCQKCFS RIILVSKRSN CPKCGSTGES GNANYRYKLS
    61  LKVAESNKLF VITVFGSCLD TFFGLTATGL HRYIQDPNKI PETLDNDTTQ NLLTKAVETC
   121  FVGQSFIFGV TNFENQPGQG SDASNFLQQC SDHKRKAKAL VACQIVLPDP GIAGFTVIDY
   181  FHQLLQTFNF RKLQCDSQAP NNHLLALDHS NSDLSSIYTS DSTSDFFKSC SKDTFSKFWQ
   241  PSLEFTCIVS QLTDNDDFSA SEQSKAFGTL QQNRKSISIA EATGSSSCHD PIQDSWSLVS
   301  YMDKKSTAEK LGKELGLQAK ELSAVHSSHH EIGVNDSNLF SLEMREPLES SNTKSFHSAV
   361  EIKNRSQHEL PCFQHHGIDT PTSLQKRSAC CPPSLLRLEE TASSSQDGDP QIWDDLPFSE
   421  SLNKFLAVLE SEIAVTQADV SSRKHHVDND IDKFHADHSR LSVTPQRTTG ALHTPPIALR
   481  SSQVIVKANC SKDDFLFNCK GNLSPSVEKE SQPDNKVEAV SVNHNGRDMS EYFLPNPYLS
   541  ALSSSSKDLE TIVTLKKTIR ISPHRESDHS SLNNKYLNGC GEISVSEMNE KLTTLCYRKY
   601  NDVSDLCKLE NKQYCRWSKN QDDSFTICRK LTYPLETLCN SPNRSTNTLK EMPWGHINNN
   661  VTQSYSIGYE GSYDASADLF DDIAKEMDIA TEITKKSQDI LLKWGTSLAE SHPSESDFSL
   721  RSLSEDFIQP SQKLSLQSLS DSRHSRTCSP TPHFQSDSEY NFENSQDFVP CSQSTPISGF
   781  HQTRIHGINR AFKKPVFYSD LDGNYEKIRI FPENDKQQAS PSCPKNIKTP SQKIRSPIVS
   841  GVSQPDVFNH YPFAECHETD SDEWVPPTTQ KIFPSDMLGF QGIGLGKCLA AYHFPDQQEL
   901  PRKKLKHIRQ GTNKGLIKKK LKNMLAAVVT KKKTHKYNCK SSGWISKCPD IQVLAAPQLH
   961  PILGPDSCSE VKCCLPFSEK GPPSVCETRS AWSPELFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDIAS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

testis: 10 nTPM
bone marrow: 7.4 nTPM
tonsil: 5.8 nTPM
thymus: 5 nTPM
lymph node: 4.1 nTPM
lung: 3.2 nTPM

Single-cell type

cardiomyocytes: 56 nCPM
differentiating spermatogonia: 31 nCPM
neutrophil progenitors: 31 nCPM
epicardial cells: 30 nCPM
monocyte progenitors: 26 nCPM
kupffer cells: 23 nCPM

Immune cell

classical monocyte: 10 nTPM
non-classical monocyte: 8.6 nTPM
intermediate monocyte: 7.9 nTPM
neutrophil: 5.5 nTPM
myeloid DC: 4.5 nTPM
eosinophil: 4.1 nTPM

Brain region

white matter: 8.1 nTPM
cerebral cortex: 6.6 nTPM
basal ganglia: 6.5 nTPM
midbrain: 6.5 nTPM
thalamus: 6.5 nTPM
hippocampal formation: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleic acid-binding, OB-fold
Replication factor A, C-terminal
Replication factor-A C terminal domain
DNA damage-induced apoptosis suppressor protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDIAS as an antibody target. Whether an autoantibody or antibody against DDIAS could matter depends on whether native DDIAS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDIAS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDIAS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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