Seroatlas · Human Serome Atlas

DCTPP1

dCTP pyrophosphatase 1

Also known as: CDA03, DCTP1_HUMAN, MGC5627, RS21C6, XTP3TPA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H773
Gene
DCTPP1
Ensembl
ENSG00000179958
Chromosome
16
Canonical length
170 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homotetramer

OverviewNCBI Gene

The protein encoded by this gene is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. The encoded protein also displays weak activity against dTTP and dATP, but none against dGTP. This protein may be responsible for eliminating excess dCTP after DNA synthesis and may prevent overmethylation of CpG islands. Three transcript variants, one protein-coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>Q9H773|DCTPP1
     1  MSVAGGEIRG DTGGEDTAAP GRFSFSPEPT LEDIRRLHAE FAAERDWEQF HQPRNLLLAL
    61  VGEVGELAEL FQWKTDGEPG PQGWSPRERA ALQEELSDVL IYLVALAARC RVDLPLAVLS
   121  KMDINRRRYP AHLARSSSRK YTELPHGAIS EDQAVGPADI PCDSTGQTST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCTPP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
55 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 55 nTPM
  • colon: 53 nTPM
  • skeletal muscle: 42 nTPM
  • tongue: 34 nTPM
  • kidney: 34 nTPM
  • tonsil: 33 nTPM

Single-cell type

  • esophageal basal cells: 170 nCPM
  • enteric transient amplifying cells: 161 nCPM
  • migrating cytotrophoblasts: 156 nCPM
  • enteric stem cells: 156 nCPM
  • colonocytes: 137 nCPM
  • cytotrophoblasts: 122 nCPM

Immune cell

  • memory B-cell: 147 nTPM
  • naive B-cell: 129 nTPM
  • plasmacytoid DC: 95 nTPM
  • myeloid DC: 87 nTPM
  • total PBMC: 81 nTPM
  • non-classical monocyte: 80 nTPM

Brain region

  • white matter: 20 nTPM
  • hypothalamus: 20 nTPM
  • choroid plexus: 19 nTPM
  • pons: 18 nTPM
  • cerebral cortex: 18 nTPM
  • cerebellum: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0.46
gnomAD missense Z
-0.2
DepMap mean gene effect
-0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • dCTP pyrophosphatase 1
  • dCTP Pyrophosphatase
  • MazG-like family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCTPP1 as an antibody target. Whether an autoantibody or antibody against DCTPP1 could matter depends on whether native DCTPP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCTPP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCTPP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DCTPP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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