Seroatlas · Human Serome Atlas

DCLRE1A

DNA cross-link repair 1A protein

Also known as: DCR1A_HUMAN, hSNM1, KIAA0086, PSO2, SNM1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PJP8
Gene: DCLRE1A
Ensembl: ENSG00000198924
Chromosome: 10
Canonical length: 1040 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

1040 residues, UniProt reviewed canonical sequence.

>Q6PJP8|DCLRE1A
     1  MLEDISEEDI WEYKSKRKPK RVDPNNGSKN ILKSVEKATD GKYQSKRSRN RKRAAEAKEV
    61  KDHEVPLGNA GCQTSVASSQ NSSCGDGIQQ TQDKETTPGK LCRTQKSQHV SPKIRPVYDG
   121  YCPNCQMPFS SLIGQTPRWH VFECLDSPPR SETECPDGLL CTSTIPFHYK RYTHFLLAQS
   181  RAGDHPFSSP SPASGGSFSE TKSGVLCSLE ERWSSYQNQT DNSVSNDPLL MTQYFKKSPS
   241  LTEASEKIST HIQTSQQALQ FTDFVENDKL VGVALRLANN SEHINLPLPE NDFSDCEISY
   301  SPLQSDEDTH DIDEKPDDSQ EQLFFTESSK DGSLEEDDDS CGFFKKRHGP LLKDQDESCP
   361  KVNSFLTRDK YDEGLYRFNS LNDLSQPISQ NNESTLPYDL ACTGGDFVLF PPALAGKLAA
   421  SVHQATKAKP DEPEFHSAQS NKQKQVIEES SVYNQVSLPL VKSLMLKPFE SQVEGYLSSQ
   481  PTQNTIRKLS SENLNAKNNT NSACFCRKAL EGVPVGKATI LNTENLSSTP APKYLKILPS
   541  GLKYNARHPS TKVMKQMDIG VYFGLPPKRK EEKLLGESAL EGINLNPVPS PNQKRSSQCK
   601  RKAEKSLSDL EFDASTLHES QLSVELSSER SQRQKKRCRK SNSLQEGACQ KRSDHLINTE
   661  SEAVNLSKVK VFTKSAHGGL QRGNKKIPES SNVGGSRKKT CPFYKKIPGT GFTVDAFQYG
   721  VVEGCTAYFL THFHSDHYAG LSKHFTFPVY CSEITGNLLK NKLHVQEQYI HPLPLDTECI
   781  VNGVKVVLLD ANHCPGAVMI LFYLPNGTVI LHTGDFRADP SMERSLLADQ KVHMLYLDTT
   841  YCSPEYTFPS QQEVIRFAIN TAFEAVTLNP HALVVCGTYS IGKEKVFLAI ADVLGSKVGM
   901  SQEKYKTLQC LNIPEINSLI TTDMCSSLVH LLPMMQINFK GLQSHLKKCG GKYNQILAFR
   961  PTGWTHSNKF TRIADVIPQT KGNISIYGIP YSEHSSYLEM KRFVQWLKPQ KIIPTVNVGT
  1021  WKSRSTMEKY FREWKLEAGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCLRE1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

liver: 9.1 nTPM
parathyroid gland: 7.9 nTPM
retina: 7.4 nTPM
pancreas: 6.9 nTPM
kidney: 5.6 nTPM
prostate: 5.5 nTPM

Single-cell type

megakaryocytes: 80 nCPM
platelets: 66 nCPM
erythrocyte progenitors: 21 nCPM
corticotrophs: 14 nCPM
megakaryocyte progenitors: 14 nCPM
monocyte progenitors: 12 nCPM

Immune cell

T-reg: 3.2 nTPM
gdT-cell: 2.8 nTPM
memory CD8 T-cell: 1.9 nTPM
MAIT T-cell: 1.8 nTPM
naive CD8 T-cell: 1.4 nTPM
basophil: 1.3 nTPM

Brain region

cerebral cortex: 7.3 nTPM
hypothalamus: 6.8 nTPM
cerebellum: 6.5 nTPM
basal ganglia: 6.4 nTPM
choroid plexus: 6.3 nTPM
thalamus: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 0.58
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCLRE1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PCNA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCLRE1A as an antibody target. Whether an autoantibody or antibody against DCLRE1A could matter depends on whether native DCLRE1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCLRE1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCLRE1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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