Seroatlas · Human Serome Atlas

DCLK3

Serine/threonine-protein kinase DCLK3

Also known as: DCAMKL3, DCDC3C, DCLK3_HUMAN, KIAA1765

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C098
Gene: DCLK3
Ensembl: ENSG00000163673
Chromosome: 3
Canonical length: 648 aa
Protein class: Enzymes, Predicted membrane proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein localization to nucleus. Predicted to act upstream of or within negative regulation of protein localization to nucleus and peptidyl-serine phosphorylation. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

648 residues, UniProt reviewed canonical sequence.

>Q9C098|DCLK3
     1  MGKEPLTLKS IQVAVEELYP NKARALTLAQ HSRAPSPRLR SRLFSKALKG DHRCGETETP
    61  KSCSEVAGCK AAMRHQGKIP EELSLDDRAR TQKKWGRGKW EPEPSSKPPR EATLEERHAR
   121  GEKHLGVEIE KTSGEIIRCE KCKRERELQQ SLERERLSLG TSELDMGKGP MYDVEKLVRT
   181  RSCRRSPEAN PASGEEGWKG DSHRSSPRNP TQELRRPSKS MDKKEDRGPE DQESHAQGAA
   241  KAKKDLVEVL PVTEEGLREV KKDTRPMSRS KHGGWLLREH QAGFEKLRRT RGEEKEAEKE
   301  KKPCMSGGRR MTLRDDQPAK LEKEPKTRPE ENKPERPSGR KPRPMGIIAA NVEKHYETGR
   361  VIGDGNFAVV KECRHRETRQ AYAMKIIDKS RLKGKEDMVD SEILIIQSLS HPNIVKLHEV
   421  YETDMEIYLI LEYVQGGDLF DAIIESVKFP EPDAALMIMD LCKALVHMHD KSIVHRDLKP
   481  ENLLVQRNED KSTTLKLADF GLAKHVVRPI FTVCGTPTYV APEILSEKGY GLEVDMWAAG
   541  VILYILLCGF PPFRSPERDQ DELFNIIQLG HFEFLPPYWD NISDAAKDLV SRLLVVDPKK
   601  RYTAHQVLQH PWIETAGKTN TVKRQKQVSP SSEGHFRSQH KRVVEQVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCLK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 4.8 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 4.8 nTPM
testis: 2.6 nTPM
retina: 1.4 nTPM
thymus: 1.2 nTPM
pituitary gland: 1 nTPM
skeletal muscle: 0.8 nTPM

Single-cell type

late primary spermatocytes: 61 nCPM
thyrotrophs: 48 nCPM
early spermatids: 32 nCPM
corticotrophs: 25 nCPM
somatotrophs: 23 nCPM
adrenal medulla cells: 21 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 9.2 nTPM
spinal cord: 3.7 nTPM
amygdala: 2.9 nTPM
cerebral cortex: 2.8 nTPM
hippocampal formation: 2.5 nTPM
hypothalamus: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.14
gnomAD missense Z: 0.8
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein localization to nucleus

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCLK3 as an antibody target. Whether an autoantibody or antibody against DCLK3 could matter depends on whether native DCLK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCLK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCLK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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