Seroatlas · Human Serome Atlas

DCHS2

Protocadherin-23

Also known as: CDH27, CDHJ, CDHR7, FLJ20047, PCD23_HUMAN, PCDH23, PCDHJ

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6V1P9
Gene: DCHS2
Ensembl: ENSG00000197410
Chromosome: 4
Canonical length: 3371 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

This gene encodes a large protein that contains many cadherin domains and likely functions in cell adhesion. Genome-wide association studies suggest that this gene may be important in Alzheimer's disease, compressive strength index, and appendicular lean mass. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

3371 residues, UniProt reviewed canonical sequence.

>Q6V1P9|DCHS2
     1  MSPCGRKMGE GRQQRRAPVG KLLLLPGRRD TPHGRSGSSG ARTQRSLLWL LVHVWLWAAS
    61  GSSAQLFNLT LSVDEGLPPD TLVGDIRAGL PAAQQQEGSG FFLSEDSDDS PLLDDFHVHP
   121  DTGIIRTARR LDRERRDHYS FVAATLLGAV VQVEIRVNDV NDHSPRFPLD SLQLDVSELS
   181  PPGTAFRLPV AHDPDAGLFS TQGYTLVQPS DLPKDPAGPF FQLRYRTPGP LPSPLLPGSS
   241  SPLEPLDLVL LRRLDREEAA AHRLQIEAWD GGRPRRTGLL SVELRVLDEN DNPPVFEQDE
   301  YRAAVREDAQ PGAEVCRVRA TDRDLGPNGF VRYSVRARQV PGAGSGGGAL GDAAYFAVEE
   361  LSGVVRVWRP LDREAQAWHQ LVVEARDGGA EPEVATVRVS IAVLDVNDNR PAIHVLFLTE
   421  GGVARVSEGA RPGDYVARVS VSDADGDWEK EDEATGELGV GLGDGSISLS LEGGEGDFAL
   481  LPGGPPGVFF LCVEGPLDRE SRDLYELLLV ATDAGSPPLS TEETLLLRVA DLNDQPPLFS
   541  QQHYKASVSE AAAPGTVVMW VSASDADEAG SDHAWLRYTV VQLSAPCNLG SLQSKMVHTA
   601  ECGPSFAIDS ESGAISTIRT LDREVQEAVE LKVVAQDLGE PPLSATCLVS ITVDDVNDNE
   661  PIFWRQVYNA TIAEHAPVGH CFLQVTASDA DSGLYGFIEY SLYDGFLSYE APQAFRIDPH
   721  DGQICVSQDI DRERDPATYD LLVEAKDGGG LSAQAFVRVD LEDVNDNHPV FNPSTYVTSI
   781  SDETQPGTEI INVLATDQDS GIYGTVAYEL IPGNVSSLFT IDSTTGIIYL TLPLSHLEST
   841  TLSLMVSAQD GGGLTAVINA DVTIHIFQTT LAPAEFERPK YTFLVYEDVP EDSPIGTVKA
   901  REPLNSSEPI FYRISSGDLG GKFSIHPRLG TIRTRKPLDH ETQPVVVLTV QAQLGSAPAC
   961  SSTEVNITVM DVNDNHPAFL RTSDEIRISQ TTPPGTALYL ARAEDRDSGR NGLIRYSIAS
  1021  PQPGVFAIDR ALGVLFLNGS LGAGEQRELT LTLRAEDQGV HPQAALLVLT VVIEKREHSP
  1081  SWTFEHLVYQ VEVSESLSPM TQMLQTQAHP LGPQRAASPL RYSLEPSVDS AMFGIRPYTG
  1141  WIYLRRQFDY ESTQTYNFRV FAWIPEDGFL QNVSTTVIVR VWDENDNSPT FLHDVLFLKV
  1201  EESPVPQGVI GKITAIDMDS GKNGQLLYFL LSDGKFFKMN PNTGELINWV ALDREHRGHH
  1261  EMTVLVTDRG SPPRNATMAV YVSVTDINDN RPFFPQCLPG KELHVKVLEG QPVNMLVTTV
  1321  FAKDPDEGNN AEVTYSVSSE DSSDHFKIDA NNGEIRTTTI LSYDYRPSYR MSVIATDQGV
  1381  PPLQGQAVVN IQVIPLSKGR AIMSQNIRHL IIPENLKPTK IMSLIKSSDH LQQHYNGKLH
  1441  FSIVADDKDG HFEIDSSTGD LFLSKELDYE TTSHYLFRVI TTDHSKNLSL SSTVFLSIDV
  1501  EDQNDHSPSF QDELIVISVE ENVPIGTLVY VFNAKDDDGS FLNSRIQYYI ESHNPGTNPF
  1561  LIHPSFGTLV TVSRLDRESI PTVILTVTAS DQAVNVTDRR LRSLTAQIVI LDVNDHNPTF
  1621  ISFPNAHVKE DVTVGSLVHH ITAHDPDEGR NGKVTYSILS GNENMTFMLD ESSGLLTTTC
  1681  PLDYEMKTQH ILTVLALDDG TPALSSSQTL TVTVLDVNDE APVFKQHLYE ASVKENQNPG
  1741  EFVTRVEALD RDSGVNSKLQ FEIMPGASFE LFEINSDTGE VVTTTILDRE IQEVFTLRVL
  1801  VRDGGFPSLS STTTILCTVE DENDHAPEFI VSSYDIEVLE NQEPEVVYTV LASDMDAGNN
  1861  RAVEYHIIDG NTDECFTINE MSGELSTTRA LDREQISNFT LVILCSDLGD PPRSSVIHLQ
  1921  VRVLDANDHS PSFPTLYYQS SVREDAEVGT VVLVLSAVDK DEGLNGQTEY FLTDEASGAF
  1981  TIDPMSGTLK TSNTLDREAR SQHTFSAVAR DCSIQGSRST TVIIKVYVTD VNDNDPVLEQ
  2041  NPFDVFLSPE SPTNQTTVIV RADDLDLGPN GTVVFSFAET QSMFSIDKYT GEIQFQQNPS
  2101  SEYFPIWLQL KVTDQGIPAR TTTGLLVIHM EGEDVKISFS HHLYKGLVTE NCEAGTSIVT
  2161  VKAFAPDSIQ DSMKYSIFSG NEDGVLSLCS KSGQLTVKEP KFLDFEVRNE VQLIVLAESS
  2221  GHRAYCKVAV LIQDENDNSP CFEQSIYQAS VSESQLYNAH VIQVFATDLD SGLNGLIEYS
  2281  ILSGNQEEAF QIDALSGVIT TKAILDYELT SSYSLIVQAT DKGMPRLSNT TVIKVQVTDI
  2341  NDNAPAFLPS EAVEITEDSL PGVIVTHVSV HDVDLNSAFI FSFAKESNPG TKFAIDQNTG
  2401  VVVLVKTLDF EEMTEYELLI QISDSVHYTE GALVVRVLDV NDNPPVFSQD FYQVTVPESI
  2461  PVGYSVLTLS ATDLESNENI SYRILSSSKE FSIDPKNGTI FTISPVLLLD TISTTQFLVE
  2521  ASDGGNPDLR ALTLVEIGIE DMNNYAPEFT VKSYNLSLSE DALVGSTLVT FSNIDHDWTR
  2581  ENTYVEYSII SGNSQNNFHV ETKFFHSEYP YKQVGYLVLL HSLDREASAS HELVILASDS
  2641  GCPPLSSTAV ISIQVLDVND NPPNFSSLSY HTHVKESTPL GSHITVVSAN DRDTGSHAEI
  2701  IYNIISGNEK GHFYLEENTG VLYLIKPLDY EKMTKFTLTV QASDAEKKHF SFAVVFVSVL
  2761  DDNDHAPQFM FSSFSCIVPE NLPISSTICS INALDFDAGP YGELTYSIVS PCFLTHGMSY
  2821  DHDLFLIDPL TGDIHAKQIL DYENGNKYCL TVQAKDKGDA TASLVVWVDI EGIDEFEPIF
  2881  TQDQYFFTLP EKNKDRQLIG RVEASDADAG IDGVILYSLG TSSPFFSVNK TNGNIYLIRA
  2941  LPLIKSQLNK EDTLEMKIIA HSPKSDSKFA SCTVFVNVSF SSEGTPLAVF ASSFSISLVV
  3001  SFLVFLILIC ILIVMILRHK QKDTINNYEE KKTSSLDADL RVTRDASVLK AFQKTDDCSN
  3061  EVVPVDATPE WLSLISIMEK DIVNLYRHSN SSGHCSVEGE TAEDKEIQRI NEHPYRKCSD
  3121  SALSDHESRV PDSGIPRDSD QLSCLSGETD VMVTAETAEA SQTFGEGDQG EGCSTTCAQN
  3181  NVLPQTVQKR EAKESILADV RKESVFISGD QEVRCAALST QTTSDHDGKD NYHWNYLLSW
  3241  EPKFQPLASV FNDIAKLKDE HLHMPGIPKE KKSFVFPPPL ITAVAQPGIK AVPPRMPAVN
  3301  LGQVPPKHPR SPIPYHLGSL PEGMTPNFSP SLSLLTMQPP ALSPLLREGE LLGTHISGTC
  3361  HELKAEDEVQ I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCHS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0
Highest tissue expression: 1.5 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 1.5 nTPM
cerebral cortex: 1.1 nTPM
endometrium: 1.1 nTPM
colon: 1 nTPM
fallopian tube: 0.7 nTPM
stomach: 0.7 nTPM

Single-cell type

astrocytes: 115 nCPM
other brain neurons: 56 nCPM
brain inhibitory neurons: 45 nCPM
brain excitatory neurons: 27 nCPM
ependymal cells: 14 nCPM
oligodendrocyte progenitor cells: 7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 4.3 nTPM
white matter: 4.1 nTPM
hypothalamus: 4 nTPM
basal ganglia: 3.3 nTPM
spinal cord: 2.9 nTPM
cerebral cortex: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: -0.5
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCHS2 as an antibody target. Whether an autoantibody or antibody against DCHS2 could matter depends on whether native DCHS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCHS2 is annotated at the cell surface, where native DCHS2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DCHS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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