Seroatlas · Human Serome Atlas

DCDC2C

Doublecortin domain-containing protein 2C

Also known as: DCD2C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MYV0
Gene
DCDC2C
Ensembl
ENSG00000214866
Chromosome
2
Canonical length
364 aa
Protein class
Predicted intracellular proteins
Subcellular location
End piece

OverviewNCBI Gene

Predicted to be involved in intracellular signal transduction. Located in cytoplasm and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>A8MYV0|DCDC2C
     1  MGTRGPSAPV DTTPAKTIVV YRNGDPFYVG KKFVLSRRRA ATFEALLEQL TEQVDVPFGV
    61  RRLFTPTRGH RVLGLDALQA GGKYVAAGRE RFKELDYIHI VPRKPAKIRK LKEIKPVVHC
   121  DINVPSKWQT YHRISRHINV FTNGRLFIPP AKIIIPKFSL SDWDIVLATI GEKVFPLGGV
   181  RKLFTMNGHL LGDSKDLQDN HFYVAVGLET FKYFPYWKSP RVPSEVQQRY ANVEKNSQRK
   241  KKVDSKGKEP CKYDGIPPKT QDSVYYAKEE KKKTLAEPLV QRGAEGDVYK APTPSKETQG
   301  ALDVKEEHNV QLEVPVDQRQ AEIVKEDEEI HENTPDFEGN KDKEDARLCE DVERKMAREW
   361  KPVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCDC2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 3 nTPM
  • choroid plexus: 1.2 nTPM
  • blood vessel: 0.7 nTPM
  • prostate: 0.4 nTPM
  • bone marrow: 0.3 nTPM
  • epididymis: 0.3 nTPM

Single-cell type

  • early spermatids: 331 nCPM
  • peritubular myoid cells: 113 nCPM
  • late spermatids: 104 nCPM
  • pituitary stem cells: 52 nCPM
  • choroid plexus epithelial cells: 49 nCPM
  • oocytes: 46 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 7.2 nTPM
  • cerebellum: 6.4 nTPM
  • cerebral cortex: 6.3 nTPM
  • white matter: 6 nTPM
  • hypothalamus: 5.9 nTPM
  • amygdala: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
1.03

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCDC2C as an antibody target. Whether an autoantibody or antibody against DCDC2C could matter depends on whether native DCDC2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCDC2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCDC2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DCDC2C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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