Seroatlas · Human Serome Atlas

DCDC2B

Doublecortin domain-containing protein 2B

Also known as: DCD2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A2VCK2
Gene: DCDC2B
Ensembl: ENSG00000222046
Chromosome: 1
Canonical length: 349 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>A2VCK2|DCDC2B
     1  MAGGSPAAKR VVVYRNGDPF FPGSQLVVTQ RRFPTMEAFL CEVTSAVQAP LAVRALYTPC
    61  HGHPVTNLAD LKNRGQYVAA GFERFHKLHY LPHRGKDPGG KSCRLQGPPV TRHLCDGAIG
   121  RQLPAGAPSY IHVFRNGDLV SPPFSLKLSQ AASQDWETVL KLLTEKVKLQ SGAVCKLCTL
   181  EGLPLSAGKE LVTGHYYVAV GEDEFKDLPY LELLVPSPSL PRGCWQPPGS KSRPHRQGAQ
   241  GHRAQVTQPS PKEPDRIKPS AFYARPQQTI QPRSKLPTLS FPSGVIGVYG APHRRKETAG
   301  ALEVADDEDT QTEEPLDQRA AQIVEEALSL ENQPGAGAAI SASAPALPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCDC2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 26 nTPM
lung: 1.6 nTPM
testis: 1 nTPM
choroid plexus: 0.8 nTPM
cervix: 0.3 nTPM
endometrium: 0.3 nTPM

Single-cell type

respiratory ciliated cells: 152 nCPM
fallopian tube ciliated cells: 149 nCPM
epididymal efferent duct ciliated cells: 85 nCPM
endometrial ciliated cells: 41 nCPM
epicardial cells: 25 nCPM
rod photoreceptor cells: 23 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 3.2 nTPM
midbrain: 1.8 nTPM
medulla oblongata: 1.4 nTPM
cerebellum: 1.2 nTPM
basal ganglia: 1.1 nTPM
cerebral cortex: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: -0.19
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular signal transduction

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCDC2B as an antibody target. Whether an autoantibody or antibody against DCDC2B could matter depends on whether native DCDC2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCDC2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCDC2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...