Seroatlas · Human Serome Atlas

DCANP1

Dendritic cell nuclear protein 1

Also known as: C5orf20, DCNP1, DCNP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TF63
Gene: DCANP1
Ensembl: ENSG00000251380
Chromosome: 5
Canonical length: 244 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q8TF63|DCANP1
     1  MHYGAATHIQ NSRSHGLETV PGHQRLERGA GGETPEFPGC HSPAPPENFG NELLPLSAPL
    61  QGLSEGLYPP GRNKTLPAGV LREGAVQFLH RGLCNSNLSS EASARPSGTQ DELHSSRRKT
   121  GQTRREGARK HLVCSFRLYP FTVHTVSPGN SHLALYQVFK AVKLCPSETS FFLSRKSLKS
   181  SDPWHPPSLS PNSWNRQAGF RAWSSHLISL SLTCSDSQSR RVSSSQQPPL HSLSSHRRAA
   241  HVPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCANP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 0.7 nTPM

Expression across tissuesHPA

Tissue

lymph node: 0.7 nTPM
spleen: 0.5 nTPM
skin: 0.4 nTPM
small intestine: 0.4 nTPM
tonsil: 0.3 nTPM
bone marrow: 0.1 nTPM

Single-cell type

pdcs: 2.5 nCPM
microglia: 0.8 nCPM
cdc: 0.3 nCPM
macrophages: 0.2 nCPM
monocyte progenitors: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

intermediate monocyte: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
myeloid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0
gnomAD pLI: 0
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCANP1 as an antibody target. Whether an autoantibody or antibody against DCANP1 could matter depends on whether native DCANP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCANP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCANP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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