Seroatlas · Human Serome Atlas

DCAF15

DDB1- and CUL4-associated factor 15

Also known as: C19orf72, DCA15_HUMAN, MGC99481

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q66K64
Gene: DCAF15
Ensembl: ENSG00000132017
Chromosome: 19
Canonical length: 600 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Mitochondria

OverviewNCBI Gene

Enables small molecule binding activity. Involved in protein polyubiquitination and regulation of natural killer cell activation. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

600 residues, UniProt reviewed canonical sequence.

>Q66K64|DCAF15
     1  MAPSSKSERN SGAGSGGGGP GGAGGKRAAG RRREHVLKQL ERVKISGQLS PRLFRKLPPR
    61  VCVSLKNIVD EDFLYAGHIF LGFSKCGRYV LSYTSSSGDD DFSFYIYHLY WWEFNVHSKL
   121  KLVRQVRLFQ DEEIYSDLYL TVCEWPSDAS KVIVFGFNTR SANGMLMNMM MMSDENHRDI
   181  YVSTVAVPPP GRCAACQDAS RAHPGDPNAQ CLRHGFMLHT KYQVVYPFPT FQPAFQLKKD
   241  QVVLLNTSYS LVACAVSVHS AGDRSFCQIL YDHSTCPLAP ASPPEPQSPE LPPALPSFCP
   301  EAAPARSSGS PEPSPAIAKA KEFVADIFRR AKEAKGGVPE EARPALCPGP SGSRCRAHSE
   361  PLALCGETAP RDSPPASEAP ASEPGYVNYT KLYYVLESGE GTEPEDELED DKISLPFVVT
   421  DLRGRNLRPM RERTAVQGQY LTVEQLTLDF EYVINEVIRH DATWGHQFCS FSDYDIVILE
   481  VCPETNQVLI NIGLLLLAFP SPTEEGQLRP KTYHTSLKVA WDLNTGIFET VSVGDLTEVK
   541  GQTSGSVWSS YRKSCVDMVM KWLVPESSGR YVNRMTNEAL HKGCSLKVLA DSERYTWIVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCAF15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

testis: 43 nTPM
spleen: 32 nTPM
cerebellum: 30 nTPM
bone marrow: 30 nTPM
skin: 29 nTPM
esophagus: 23 nTPM

Single-cell type

microglia: 19 nCPM
bergmann glia: 15 nCPM
brain excitatory neurons: 14 nCPM
astrocytes: 14 nCPM
oligodendrocyte progenitor cells: 12 nCPM
renal collecting duct principal cells: 11 nCPM

Immune cell

eosinophil: 1.3 nTPM
neutrophil: 0.7 nTPM
memory B-cell: 0.5 nTPM
memory CD8 T-cell: 0.5 nTPM
T-reg: 0.5 nTPM
classical monocyte: 0.4 nTPM

Brain region

white matter: 16 nTPM
hypothalamus: 13 nTPM
hippocampal formation: 13 nTPM
medulla oblongata: 12 nTPM
cerebral cortex: 12 nTPM
amygdala: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 0.99
gnomAD missense Z: 2.27
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Cul4-RING E3 ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

DDB1- and CUL4-associated factor 15, WD40 repeat-containing domain
DDB1- and CUL4-associated factor 15
DDB1- and CUL4-associated factor 15, C-terminal domain
DDB1-and CUL4-substrate receptor 15, WD repeat

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCAF15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DDB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCAF15 as an antibody target. Whether an autoantibody or antibody against DCAF15 could matter depends on whether native DCAF15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCAF15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCAF15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...