DCAF12L2

Protein identityUniProt · HPA

UniProt accession

Q5VW00

Gene

DCAF12L2

Ensembl

ENSG00000198354

Chromosome

X

Canonical length

463 aa

Protein class

Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multi-protein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 9. However, the CDS of this intronless gene remains intact, it is conserved in other mammalian species, it is known to be transcribed, and it is therefore thought to encode a functional protein. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

463 residues, UniProt reviewed canonical sequence.

>Q5VW00|DCAF12L2
     1  MAQQQTGSRK RKAPAVEAGA GSSSSQGLAA ADGEGPLLPK KQKRPATRRR LVHYLKGREV
    61  GARGPAGLQG FEGELRGYAV QRLPELLTER QLDLGTLNKV FASQWLNARQ VVCGTKCNTL
   121  FVVDVQSGHI TRIPLMRDKE AGLAQAHQGC GIHAIELNPS KTLLATGGEN PNSLAIYQLP
   181  TLDPLCLGDR HGHKDWIFAV AWLSDTVAVS GSRDGTVALW RMDPDMFNGS IAWHSEVGLP
   241  VYAHIRPRDV EAIPRASTNP SNRKVRALAF SGKNQELGAV SLDGYFHLWK ARSTLSRLLS
   301  IRLPYCRENV CLTYCDELSL YAVGSQSHVS FLDPRQRQQN IRPLCSREGG TGVRSLSFYQ
   361  HIITVGTGHG SLLFYDIRAQ KFLEERASSS LDSMPGPAGR KLKLACGRGW LNQDDVWVNY
   421  FGGMGEFPNA LYTHCYNWPE MKLFVAGGPL PSGLHGNYAG LWS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCAF12L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

20 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.04

gnomAD pLI

0.01

gnomAD missense Z

0.94

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

• Cul4-RING E3 ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

• WD40 repeat
• WD40/YVTN repeat-like-containing domain superfamily
• WD40-repeat-containing domain superfamily
• DDB1-CUL4-associated factor 12
• DDB1- and CUL4-associated factor 12, beta-propeller domain
• DDB1- and CUL4-associated factor 12 beta propeller

KeywordsUniProt

• Repeat
• WD repeat