Seroatlas · Human Serome Atlas

DCAF10

DDB1- and CUL4-associated factor 10

Also known as: DCA10_HUMAN, FLJ23201, MGC10765, WDR32

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5QP82
Gene: DCAF10
Ensembl: ENSG00000122741
Chromosome: 9
Canonical length: 559 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to be involved in protein ubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

559 residues, UniProt reviewed canonical sequence.

>Q5QP82|DCAF10
     1  MFPFGPHSPG GDGSAGAGAE EPTPHEGQAA ATGPPSPLHP GADATHPPPP ARSPRRPGAP
    61  SLSPAPRSGE LGLPGAPESS TASAPGEPSP PSPPCRRPGP DCRAKSRGRH GLGAGLGGPG
   121  ARLFGWLKER SLGRGLFVDP ARDNFRTMTS LYGSIHPADS VYLSTRTHGA VFNLEYSPDG
   181  SVLTVACEQT EVLLFDPISS KHIKTLSEAH EDCVNNIRFL DNRLFATCSD DTTIALWDLR
   241  KLNTKVCTLH GHTSWVKNIE YDTNTRLLVT SGFDGNVIIW DTNRYTEDGC PHKKFFHTRF
   301  LMRMRLTPDC SKMLISTSSG YLLILHDLDL TKSLEVGSYP ILRARRTTSS SDLTTSSSSS
   361  GPRVSGSPCH HSDSNSSEKH MSRASQREGV SPRNSLEVVT PEVLGESDHG NCITSLQLHP
   421  KGWATLLRCS SNSDDEECTC VYEFQEGAPV RPVSPRCSLR LTHYIEEANV GRGYIKELCF
   481  SPDGRMISSP HGYGIRLLGF DKQCSELVDC LPKEASPLRV IRSLYSHNDV VLTTKFSPTH
   541  CQIASGCLSG RVSLYQPKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCAF10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 13 nTPM
liver: 11 nTPM
thyroid gland: 8.4 nTPM
adrenal gland: 8.3 nTPM
kidney: 7.9 nTPM
pancreas: 7.9 nTPM

Single-cell type

late spermatids: 571 nCPM
neutrophil progenitors: 261 nCPM
adrenal cortex cells: 251 nCPM
sertoli cells: 247 nCPM
myonuclei: 246 nCPM
late primary spermatocytes: 243 nCPM

Immune cell

non-classical monocyte: 0.8 nTPM
naive B-cell: 0.6 nTPM
naive CD4 T-cell: 0.6 nTPM
neutrophil: 0.6 nTPM
NK-cell: 0.6 nTPM
eosinophil: 0.5 nTPM

Brain region

choroid plexus: 14 nTPM
cerebellum: 13 nTPM
basal ganglia: 11 nTPM
cerebral cortex: 11 nTPM
midbrain: 11 nTPM
white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.8
gnomAD missense Z: 2.73
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein ubiquitination

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
DDB1- and CUL4-associated factor 10

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCAF10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DDB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCAF10 as an antibody target. Whether an autoantibody or antibody against DCAF10 could matter depends on whether native DCAF10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCAF10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCAF10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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