Seroatlas · Human Serome Atlas

DBX2

Homeobox protein DBX2

Also known as: DBX2_HUMAN, FLJ16139

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNG2
Gene: DBX2
Ensembl: ENSG00000185610
Chromosome: 12
Canonical length: 339 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear membrane,Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including G2/M transition of mitotic cell cycle; epidermal growth factor receptor signaling pathway; and neural precursor cell proliferation. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>Q6ZNG2|DBX2
     1  MLPSAVAAHA GAYWDVVASS ALLNLPAAPG FGNLGKSFLI ENLLRVGGAP TPRLQPPAPH
    61  DPATALATAG AQLRPLPASP VPLKLCPAAE QVSPAGAPYG TRWAFQVLSP SADSARLPGR
   121  APGDRDCTFQ PSAPAPSKPF LLSTPPFYSA CCGGSCRRPA SSTAFPREES MLPLLTQDSN
   181  SKARRGILRR AVFSEDQRKA LEKMFQKQKY ISKTDRKKLA INLGLKESQV KIWFQNRRMK
   241  WRNSKEKEVL SNRCIQEVGL QEDPLSRSAL GFPSPCPSIW DVPQQHSSPR WRENSPEPSE
   301  RLIQESSGAP PPEANSLQGA LYLCSEEEAG SKGVLTGAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DBX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 3.4 nTPM

Expression across tissuesHPA

Tissue

midbrain: 3.4 nTPM
cerebral cortex: 2.6 nTPM
hypothalamus: 2.6 nTPM
spinal cord: 2.4 nTPM
amygdala: 2.2 nTPM
basal ganglia: 1.9 nTPM

Single-cell type

oligodendrocyte progenitor cells: 22 nCPM
astrocytes: 17 nCPM
undifferentiated spermatogonia: 12 nCPM
fibro-adipogenic progenitors: 10 nCPM
adipocytes: 8.6 nCPM
bergmann glia: 5.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

spinal cord: 19 nTPM
medulla oblongata: 17 nTPM
white matter: 14 nTPM
thalamus: 10 nTPM
midbrain: 9.1 nTPM
pons: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DBX2 as an antibody target. Whether an autoantibody or antibody against DBX2 could matter depends on whether native DBX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DBX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DBX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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