Seroatlas · Human Serome Atlas

DBX1

Homeobox protein DBX1

Also known as: DBX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NMT0
Gene: DBX1
Ensembl: ENSG00000109851
Chromosome: 11
Canonical length: 343 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation in spinal cord and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within ventral spinal cord interneuron specification. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>A6NMT0|DBX1
     1  MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP PAYLPRSVPT
    61  ASMSPPRQGA PTALTDTGAS DLGSPGPGSR RGGSPPTAFS PASETTFLKF GVNAILSSGP
   121  RTETSPALLQ SVPPKTFAFP YFEGSFQPFI RSSYFPASSS VVPIPGTFSW PLAARGKPRR
   181  GMLRRAVFSD VQRKALEKMF QKQKYISKPD RKKLAAKLGL KDSQVKIWFQ NRRMKWRNSK
   241  ERELLSSGGC REQTLPTKLN PHPDLSDVGQ KGPGNEEEEE GPGSPSHRLA YHASSDPQHL
   301  RDPRLPGPLP PSPAHSSSPG KPSDFSDSEE EEEGEEQEEI TVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DBX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

cardiomyocytes: 0.8 nCPM
undifferentiated spermatogonia: 0.2 nCPM
bergmann glia: 0.1 nCPM
early primary spermatocytes: 0.1 nCPM
late primary spermatocytes: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0.2 nTPM
hypothalamus: 0.2 nTPM
medulla oblongata: 0.2 nTPM
midbrain: 0.2 nTPM
pons: 0.2 nTPM
spinal cord: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.06
gnomAD missense Z: -0.12

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DBX1 as an antibody target. Whether an autoantibody or antibody against DBX1 could matter depends on whether native DBX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DBX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DBX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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