Seroatlas · Human Serome Atlas

DBNDD1

Dysbindin domain-containing protein 1

Also known as: DBND1_HUMAN, FLJ12582, MGC3101

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H9R9
Gene: DBNDD1
Ensembl: ENSG00000003249
Chromosome: 16
Canonical length: 158 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol,Equatorial segment,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to be involved in regulation of signal transduction. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

158 residues, UniProt reviewed canonical sequence.

>Q9H9R9|DBNDD1
     1  MEPPEGAGTG EIVKEAEVPQ AALGVPAQGT GDNGHTPVEE EVGGIPVPAP GLLQVTERRQ
    61  PLSSVSSLEV HFDLLDLTEL TDMSDQELAE VFADSDDENL NTESPAGLHP LPRAGYLRSP
   121  SWTRTRAEQS HEKQPLGDPE RQATVLDTFL TVERPQED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DBNDD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 92 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 92 nTPM
amygdala: 60 nTPM
skeletal muscle: 47 nTPM
hippocampal formation: 46 nTPM
midbrain: 42 nTPM
cerebellum: 38 nTPM

Single-cell type

esophageal apical cells: 69 nCPM
cardiomyocytes: 46 nCPM
esophageal suprabasal cells: 37 nCPM
cholangiocytes: 32 nCPM
breast lactating cells: 23 nCPM
epicardial cells: 18 nCPM

Immune cell

naive B-cell: 13 nTPM
naive CD4 T-cell: 2.9 nTPM
memory B-cell: 1.2 nTPM
total PBMC: 1 nTPM
eosinophil: 0.7 nTPM
memory CD4 T-cell: 0.6 nTPM

Brain region

thalamus: 180 nTPM
cerebral cortex: 111 nTPM
midbrain: 104 nTPM
pons: 93 nTPM
amygdala: 86 nTPM
hypothalamus: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of signal transduction

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DBNDD1 as an antibody target. Whether an autoantibody or antibody against DBNDD1 could matter depends on whether native DBNDD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DBNDD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DBNDD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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