DBI

Protein identityUniProt · HPA

UniProt accession

P07108

Gene

DBI

Ensembl

ENSG00000155368

Chromosome

2

Canonical length

87 aa

Protein class

Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

87 residues, UniProt reviewed canonical sequence.

>P07108|DBI
     1  MSQAEFEKAA EEVRHLKTKP SDEEMLFIYG HYKQATVGDI NTERPGMLDF TGKAKWDAWN
    61  ELKGTSKEDA MKAYINKVEE LKKKYGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DBI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

1,095 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.47

gnomAD pLI

0

gnomAD missense Z

0.06

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• fatty acid metabolic process
• phosphatidylcholine acyl-chain remodeling
• positive regulation of phospholipid transport

Molecular functions

• benzodiazepine receptor binding
• fatty-acyl-CoA binding
• identical protein binding
• long-chain fatty acyl-CoA binding

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum lumen
• extracellular exosome
• Golgi apparatus
• perinuclear endoplasmic reticulum
• protein-lipid complex

Protein domainsUniProt · Pfam · InterPro

• Acyl-CoA-binding protein, ACBP
• FERM/acyl-CoA-binding protein superfamily
• Acyl-CoA-binding protein, ACBP, conserved site
• Acyl-CoA binding protein superfamily
• Acyl CoA binding protein

KeywordsUniProt

• Acetylation
• Alternative promoter usage
• Endoplasmic reticulum
• Golgi apparatus
• Hydroxylation
• Lipid-binding
• Phosphoprotein
• Transport