Seroatlas · Human Serome Atlas

DAP

Death-associated protein 1

Also known as: DAP1, DAP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51397
Gene: DAP
Ensembl: ENSG00000112977
Chromosome: 5
Canonical length: 102 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Mitochondria

OverviewNCBI Gene

This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

102 residues, UniProt reviewed canonical sequence.

>P51397|DAP
     1  MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDTKEEK DKDDQEWESP SPPKPTVFIS
    61  GVIARGDKDF PPAAAQVAHQ KPHASMDKHP SPRTQHIQQP RK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 232 nTPM

Expression across tissuesHPA

Tissue

pancreas: 232 nTPM
choroid plexus: 182 nTPM
liver: 156 nTPM
salivary gland: 122 nTPM
kidney: 121 nTPM
blood vessel: 120 nTPM

Single-cell type

breast lactating cells: 500 nCPM
pancreatic acinar cells: 292 nCPM
platelets: 256 nCPM
choroid plexus epithelial cells: 242 nCPM
prostatic club cells: 240 nCPM
renal collecting duct intercalated cells: 187 nCPM

Immune cell

classical monocyte: 78 nTPM
myeloid DC: 77 nTPM
non-classical monocyte: 72 nTPM
intermediate monocyte: 71 nTPM
neutrophil: 64 nTPM
plasmacytoid DC: 62 nTPM

Brain region

choroid plexus: 150 nTPM
medulla oblongata: 43 nTPM
midbrain: 37 nTPM
thalamus: 36 nTPM
hippocampal formation: 32 nTPM
spinal cord: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: 0.44
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ribosome binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DAP as an antibody target. Whether an autoantibody or antibody against DAP could matter depends on whether native DAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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