Seroatlas · Human Serome Atlas

DAGLB

Diacylglycerol lipase-beta

Also known as: DAGLBETA, DGLB_HUMAN, KCCR13L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCG7
Gene: DAGLB
Ensembl: ENSG00000164535
Chromosome: 7
Canonical length: 672 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Enables lipase activity. Involved in arachidonate metabolic process. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

672 residues, UniProt reviewed canonical sequence.

>Q8NCG7|DAGLB
     1  MPGMVLFGRR WAIASDDLVF PGFFELVVRV LWWIGILTLY LMHRGKLDCA GGALLSSYLI
    61  VLMILLAVVI CTVSAIMCVS MRGTICNPGP RKSMSKLLYI RLALFFPEMV WASLGAAWVA
   121  DGVQCDRTVV NGIIATVVVS WIIIAATVVS IIIVFDPLGG KMAPYSSAGP SHLDSHDSSQ
   181  LLNGLKTAAT SVWETRIKLL CCCIGKDDHT RVAFSSTAEL FSTYFSDTDL VPSDIAAGLA
   241  LLHQQQDNIR NNQEPAQVVC HAPGSSQEAD LDAELENCHH YMQFAAAAYG WPLYIYRNPL
   301  TGLCRIGGDC CRSRTTDYDL VGGDQLNCHF GSILHTTGLQ YRDFIHVSFH DKVYELPFLV
   361  ALDHRKESVV VAVRGTMSLQ DVLTDLSAES EVLDVECEVQ DRLAHKGISQ AARYVYQRLI
   421  NDGILSQAFS IAPEYRLVIV GHSLGGGAAA LLATMLRAAY PQVRCYAFSP PRGLWSKALQ
   481  EYSQSFIVSL VLGKDVIPRL SVTNLEDLKR RILRVVAHCN KPKYKILLHG LWYELFGGNP
   541  NNLPTELDGG DQEVLTQPLL GEQSLLTRWS PAYSFSSDSP LDSSPKYPPL YPPGRIIHLQ
   601  EEGASGRFGC CSAAHYSAKW SHEAEFSKIL IGPKMLTDHM PDILMRALDS VVSDRAACVS
   661  CPAQGVSSVD VA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DAGLB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 15 nTPM
bone marrow: 14 nTPM
skeletal muscle: 13 nTPM
skin: 12 nTPM
cerebral cortex: 12 nTPM
basal ganglia: 9.7 nTPM

Single-cell type

microglia: 98 nCPM
neutrophil progenitors: 78 nCPM
endometrial glandular cells: 71 nCPM
alveolar cells type 1: 66 nCPM
macrophages: 65 nCPM
thymocytes: 59 nCPM

Immune cell

myeloid DC: 29 nTPM
classical monocyte: 23 nTPM
eosinophil: 22 nTPM
intermediate monocyte: 21 nTPM
non-classical monocyte: 20 nTPM
total PBMC: 12 nTPM

Brain region

cerebral cortex: 19 nTPM
white matter: 19 nTPM
medulla oblongata: 17 nTPM
basal ganglia: 17 nTPM
hypothalamus: 15 nTPM
hippocampal formation: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: -1.28
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DAGLB as an antibody target. Whether an autoantibody or antibody against DAGLB could matter depends on whether native DAGLB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DAGLB is annotated at the cell surface, where native DAGLB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DAGLB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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