Seroatlas · Human Serome Atlas

CZIB

CXXC motif containing zinc binding protein

Also known as: C1orf123, CZIB_HUMAN, FLJ20580

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWV4
Gene: CZIB
Ensembl: ENSG00000162384
Chromosome: 1
Canonical length: 160 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Mitotic spindle,Cytosol

OverviewNCBI Gene

Enables zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>Q9NWV4|CZIB
     1  MGKIALQLKA TLENITNLRP VGEDFRWYLK MKCGNCGEIS DKWQYIRLMD SVALKGGRGS
    61  ASMVQKCKLC ARENSIEILS STIKPYNAED NENFKTIVEF ECRGLEPVDF QPQAGFAAEG
   121  VESGTAFSDI NLQEKDWTDY DEKAQESVGI YEVTHQFVKC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CZIB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 77 nTPM
skeletal muscle: 73 nTPM
colon: 63 nTPM
tongue: 61 nTPM
urinary bladder: 58 nTPM
choroid plexus: 57 nTPM

Single-cell type

late spermatids: 391 nCPM
late primary spermatocytes: 167 nCPM
decidual stromal cells: 167 nCPM
smooth muscle cells: 101 nCPM
epididymal principal cells: 96 nCPM
early spermatids: 95 nCPM

Immune cell

intermediate monocyte: 72 nTPM
myeloid DC: 69 nTPM
T-reg: 68 nTPM
basophil: 61 nTPM
non-classical monocyte: 61 nTPM
NK-cell: 59 nTPM

Brain region

white matter: 22 nTPM
cerebral cortex: 20 nTPM
medulla oblongata: 20 nTPM
basal ganglia: 20 nTPM
thalamus: 19 nTPM
cerebellum: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

CXXC motif containing zinc binding protein, eukaryotic
CXXC motif containing zinc binding protein, eukaryotic

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CZIB as an antibody target. Whether an autoantibody or antibody against CZIB could matter depends on whether native CZIB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CZIB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CZIB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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