Seroatlas · Human Serome Atlas

CYYR1

Cysteine and tyrosine-rich protein 1

Also known as: C21orf95, CYYR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96J86
Gene
CYYR1
Ensembl
ENSG00000166265
Chromosome
21
Canonical length
154 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>Q96J86|CYYR1
     1  MDAPRLPVRP GVLLPKLVLL FVYADDCLAQ CGKDCKSYCC DGTTPYCCSY YAYIGNILSG
    61  TAIAGIVFGI VFIMGVIAGI AICICMCMKN HRATRVGILR TTHINTVSSY PGPPPYGHDH
   121  EMEYCADLPP PYSPTPQGPA QRSPPPPYPG NARK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYYR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 44 nTPM
  • adipose tissue: 34 nTPM
  • placenta: 34 nTPM
  • spleen: 31 nTPM
  • tongue: 30 nTPM
  • breast: 29 nTPM

Single-cell type

  • vascular endothelial cells: 421 nCPM
  • adrenal cortex cells: 333 nCPM
  • neutrophil progenitors: 138 nCPM
  • medullary thymic epithelial cells: 130 nCPM
  • pdcs: 89 nCPM
  • hematopoietic stem cells: 71 nCPM

Immune cell

  • plasmacytoid DC: 32 nTPM
  • myeloid DC: 0.8 nTPM
  • neutrophil: 0.3 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • midbrain: 12 nTPM
  • thalamus: 12 nTPM
  • pons: 12 nTPM
  • medulla oblongata: 9.8 nTPM
  • amygdala: 9.3 nTPM
  • spinal cord: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0
gnomAD missense Z
-0.49
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Cysteine and tyrosine-rich protein 1
  • Cysteine and tyrosine-rich protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYYR1 as an antibody target. Whether an autoantibody or antibody against CYYR1 could matter depends on whether native CYYR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYYR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYYR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CYYR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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