Seroatlas · Human Serome Atlas

CYTL1

Cytokine-like protein 1

Also known as: C17, C4orf4, CYTL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRR1
Gene: CYTL1
Ensembl: ENSG00000170891
Chromosome: 4
Canonical length: 136 aa
Protein class: Plasma proteins, Predicted secreted proteins
Subcellular location: Nuclear membrane,Endoplasmic reticulum
Secretome location: Secreted in other tissues

OverviewNCBI Gene

C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker (Liu et al., 2000 [PubMed 10857752]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

136 residues, UniProt reviewed canonical sequence.

>Q9NRR1|CYTL1
     1  MRTPGPLPVL LLLLAGAPAA RPTPPTCYSR MRALSQEITR DFNLLQVSEP SEPCVRYLPR
    61  LYLDIHNYCV LDKLRDFVAS PPCWKVAQVD SLKDKARKLY TIMNSFCRRD LVFLLDDCNA
   121  LEYPIPVTTV LPDRQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYTL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 198 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 198 nTPM
placenta: 43 nTPM
seminal vesicle: 14 nTPM
bone marrow: 13 nTPM
cervix: 12 nTPM
urinary bladder: 11 nTPM

Single-cell type

megakaryocyte-erythroid progenitors: 271 nCPM
erythrocyte progenitors: 115 nCPM
hematopoietic stem cells: 93 nCPM
microglia: 78 nCPM
megakaryocyte progenitors: 49 nCPM
vascular endothelial cells: 31 nCPM

Immune cell

NK-cell: 27 nTPM
basophil: 2.5 nTPM
classical monocyte: 1.2 nTPM
total PBMC: 0.9 nTPM
memory CD8 T-cell: 0.7 nTPM
naive CD8 T-cell: 0.7 nTPM

Brain region

white matter: 8.2 nTPM
medulla oblongata: 7.6 nTPM
pons: 5.7 nTPM
thalamus: 5.4 nTPM
spinal cord: 5.1 nTPM
choroid plexus: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

signaling receptor binding

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

Cytokine-like protein 1
Cytokine-like protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYTL1 as an antibody target. Whether an autoantibody or antibody against CYTL1 could matter depends on whether native CYTL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYTL1 is annotated as secreted, so native CYTL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CYTL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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