Seroatlas · Human Serome Atlas

CYP4Z2P

Putative inactive cytochrome P450 family member 4Z2

Also known as: CP4Z2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1L4
Gene: CYP4Z2P
Canonical length: 340 aa

OverviewNCBI Gene

No narrative summary is available for CYP4Z2P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q8N1L4|CYP4Z2P
     1  MEPSWLQELM AHPFLLLILL CMSLLLFQVI RLYQRRRWTI RAMHLFPAPP AHWFYGHKES
    61  YPVKEFEVYP ELMEKYPCAV PLWVGPFTMF FNIHDPDYVK ILLKRQDPKS AVSHKILESW
   121  VGRGLVTLDG SKWKKHRQIV KPGFNISILK IFITMMSKSV RMMLNKWEEH IAQNSRLELF
   181  QHVSLMTLDS IMKCAFSHQG SIQLDSTLDS YLKAVFNLSK ISNQRMNNFL HHNDLVFKFS
   241  SQGQIFSKFN QELHQFTEKV IQDRKESLKD KLKQDTTQKR RQDFLDILLS AKSENTKDFS
   301  EADLQAEVKT FMFAGHDTTT TAISWIFYCL AKYPEHQQRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYP4Z2P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYP4Z2P as an antibody target. Whether an autoantibody or antibody against CYP4Z2P could matter depends on whether native CYP4Z2P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYP4Z2P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYP4Z2P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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