Seroatlas · Human Serome Atlas

CYP4F3

Cytochrome P450 4F3

Also known as: CP4F3_HUMAN, CYP4F, LTB4H

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q08477
Gene
CYP4F3
Ensembl
ENSG00000186529
Chromosome
19
Canonical length
520 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2019]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q08477|CYP4F3
     1  MPQLSLSSLG LWPMAASPWL LLLLVGASWL LARILAWTYT FYDNCCRLRC FPQPPKRNWF
    61  LGHLGLIHSS EEGLLYTQSL ACTFGDMCCW WVGPWHAIVR IFHPTYIKPV LFAPAAIVPK
   121  DKVFYSFLKP WLGDGLLLSA GEKWSRHRRM LTPAFHFNIL KPYMKIFNES VNIMHAKWQL
   181  LASEGSARLD MFEHISLMTL DSLQKCVFSF DSHCQEKPSE YIAAILELSA LVTKRHQQIL
   241  LYIDFLYYLT PDGQRFRRAC RLVHDFTDAV IQERRRTLPS QGVDDFLQAK AKSKTLDFID
   301  VLLLSKDEDG KKLSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QERCRQEVQE
   361  LLKDREPKEI EWDDLAQLPF LTMCIKESLR LHPPVPAVSR CCTQDIVLPD GRVIPKGIIC
   421  LISVFGTHHN PAVWPDPEVY DPFRFDPKNI KERSPLAFIP FSAGPRNCIG QAFAMAEMKV
   481  VLGLTLLRFR VLPDHTEPRR KPELVLRAEG GLWLRVEPLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYP4F3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
218 nTPM

Expression across tissuesHPA

Tissue

  • liver: 218 nTPM
  • bone marrow: 76 nTPM
  • kidney: 26 nTPM
  • esophagus: 25 nTPM
  • gallbladder: 15 nTPM
  • small intestine: 14 nTPM

Single-cell type

  • neutrophil progenitors: 960 nCPM
  • hepatocytes: 697 nCPM
  • neutrophils: 443 nCPM
  • proximal tubule cells: 140 nCPM
  • esophageal apical cells: 106 nCPM
  • neuroendocrine cells: 80 nCPM

Immune cell

  • neutrophil: 84 nTPM
  • eosinophil: 1.3 nTPM
  • classical monocyte: 0.4 nTPM
  • basophil: 0.2 nTPM
  • myeloid DC: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM

Brain region

  • white matter: 9.4 nTPM
  • basal ganglia: 7.9 nTPM
  • midbrain: 7.5 nTPM
  • medulla oblongata: 7.2 nTPM
  • cerebellum: 6.1 nTPM
  • hypothalamus: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.38
gnomAD pLI
0
gnomAD missense Z
-0.9
DepMap mean gene effect
0.22
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYP4F3 as an antibody target. Whether an autoantibody or antibody against CYP4F3 could matter depends on whether native CYP4F3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYP4F3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYP4F3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CYP4F3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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