Seroatlas · Human Serome Atlas

CYP4A11

Cytochrome P450 4A11

Also known as: CP4AB_HUMAN, CYP4A2, CYP4AII

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q02928
Gene
CYP4A11
Ensembl
ENSG00000187048
Chromosome
1
Canonical length
519 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

519 residues, UniProt reviewed canonical sequence.

>Q02928|CYP4A11
     1  MSVSVLSPSR LLGDVSGILQ AASLLILLLL LIKAVQLYLH RQWLLKALQQ FPCPPSHWLF
    61  GHIQELQQDQ ELQRIQKWVE TFPSACPHWL WGGKVRVQLY DPDYMKVILG RSDPKSHGSY
   121  RFLAPWIGYG LLLLNGQTWF QHRRMLTPAF HYDILKPYVG LMADSVRVML DKWEELLGQD
   181  SPLEVFQHVS LMTLDTIMKC AFSHQGSIQV DRNSQSYIQA ISDLNNLVFS RVRNAFHQND
   241  TIYSLTSAGR WTHRACQLAH QHTDQVIQLR KAQLQKEGEL EKIKRKRHLD FLDILLLAKM
   301  ENGSILSDKD LRAEVDTFMF EGHDTTASGI SWILYALATH PKHQERCREE IHSLLGDGAS
   361  ITWNHLDQMP YTTMCIKEAL RLYPPVPGIG RELSTPVTFP DGRSLPKGIM VLLSIYGLHH
   421  NPKVWPNPEV FDPFRFAPGS AQHSHAFLPF SGGSRNCIGK QFAMNELKVA TALTLLRFEL
   481  LPDPTRIPIP IARLVLKSKN GIHLRLRRLP NPCEDKDQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYP4A11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
795 nTPM

Expression across tissuesHPA

Tissue

  • liver: 795 nTPM
  • kidney: 203 nTPM
  • duodenum: 1.4 nTPM
  • epididymis: 1.3 nTPM
  • small intestine: 1.1 nTPM
  • gallbladder: 1 nTPM

Single-cell type

  • hepatocytes: 679 nCPM
  • proximal tubule cells: 157 nCPM
  • epicardial cells: 39 nCPM
  • cholangiocytes: 32 nCPM
  • fibro-adipogenic progenitors: 8.8 nCPM
  • adipocytes: 5.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 1 nTPM
  • medulla oblongata: 0.6 nTPM
  • pons: 0.6 nTPM
  • cerebral cortex: 0.5 nTPM
  • hypothalamus: 0.5 nTPM
  • spinal cord: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.64
gnomAD pLI
0
gnomAD missense Z
-1.12
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYP4A11 as an antibody target. Whether an autoantibody or antibody against CYP4A11 could matter depends on whether native CYP4A11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYP4A11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYP4A11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CYP4A11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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