Seroatlas · Human Serome Atlas

CYP3A7

Cytochrome P450 3A7

Also known as: CP37, CP3A7_HUMAN, P450-HFLA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P24462
Gene
CYP3A7
Ensembl
ENSG00000160870
Chromosome
7
Canonical length
503 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

503 residues, UniProt reviewed canonical sequence.

>P24462|CYP3A7
     1  MDLIPNLAVE TWLLLAVSLI LLYLYGTRTH GLFKKLGIPG PTPLPFLGNA LSFRKGYWTF
    61  DMECYKKYRK VWGIYDCQQP MLAITDPDMI KTVLVKECYS VFTNRRPFGP VGFMKNAISI
   121  AEDEEWKRIR SLLSPTFTSG KLKEMVPIIA QYGDVLVRNL RREAETGKPV TLKHVFGAYS
   181  MDVITSTSFG VSIDSLNNPQ DPFVENTKKL LRFNPLDPFV LSIKVFPFLT PILEALNITV
   241  FPRKVISFLT KSVKQIKEGR LKETQKHRVD FLQLMIDSQN SKDSETHKAL SDLELMAQSI
   301  IFIFAGYETT SSVLSFIIYE LATHPDVQQK VQKEIDTVLP NKAPPTYDTV LQLEYLDMVV
   361  NETLRLFPVA MRLERVCKKD VEINGMFIPK GVVVMIPSYV LHHDPKYWTE PEKFLPERFS
   421  KKNKDNIDPY IYTPFGSGPR NCIGMRFALV NMKLALVRVL QNFSFKPCKE TQIPLKLRFG
   481  GLLLTEKPIV LKAESRDETV SGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYP3A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
285 nTPM

Expression across tissuesHPA

Tissue

  • liver: 285 nTPM
  • kidney: 7.9 nTPM
  • gallbladder: 6.1 nTPM
  • breast: 2.5 nTPM
  • lung: 2.3 nTPM
  • small intestine: 1.7 nTPM

Single-cell type

  • cholangiocytes: 5.9 nCPM
  • hepatocytes: 0.9 nCPM
  • basal prostatic cells: 0.6 nCPM
  • cardiomyocytes: 0.3 nCPM
  • prostatic club cells: 0.1 nCPM
  • adipocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.5 nTPM
  • medulla oblongata: 0.4 nTPM
  • hypothalamus: 0.3 nTPM
  • basal ganglia: 0.2 nTPM
  • cerebellum: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0
gnomAD missense Z
-0.27
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYP3A7 as an antibody target. Whether an autoantibody or antibody against CYP3A7 could matter depends on whether native CYP3A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYP3A7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYP3A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CYP3A7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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