Seroatlas · Human Serome Atlas

CYP3A5

Cytochrome P450 3A5

Also known as: CP35, CP3A5_HUMAN, P450PCN3, PCN3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P20815
Gene
CYP3A5
Ensembl
ENSG00000106258
Chromosome
7
Canonical length
502 aa
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

502 residues, UniProt reviewed canonical sequence.

>P20815|CYP3A5
     1  MDLIPNLAVE TWLLLAVSLV LLYLYGTRTH GLFKRLGIPG PTPLPLLGNV LSYRQGLWKF
    61  DTECYKKYGK MWGTYEGQLP VLAITDPDVI RTVLVKECYS VFTNRRSLGP VGFMKSAISL
   121  AEDEEWKRIR SLLSPTFTSG KLKEMFPIIA QYGDVLVRNL RREAEKGKPV TLKDIFGAYS
   181  MDVITGTSFG VNIDSLNNPQ DPFVESTKKF LKFGFLDPLF LSIILFPFLT PVFEALNVSL
   241  FPKDTINFLS KSVNRMKKSR LNDKQKHRLD FLQLMIDSQN SKETESHKAL SDLELAAQSI
   301  IFIFAGYETT SSVLSFTLYE LATHPDVQQK LQKEIDAVLP NKAPPTYDAV VQMEYLDMVV
   361  NETLRLFPVA IRLERTCKKD VEINGVFIPK GSMVVIPTYA LHHDPKYWTE PEEFRPERFS
   421  KKKDSIDPYI YTPFGTGPRN CIGMRFALMN MKLALIRVLQ NFSFKPCKET QIPLKLDTQG
   481  LLQPEKPIVL KVDSRDGTLS GE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYP3A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
319 nTPM

Expression across tissuesHPA

Tissue

  • liver: 319 nTPM
  • small intestine: 167 nTPM
  • duodenum: 120 nTPM
  • stomach: 82 nTPM
  • pancreas: 49 nTPM
  • gallbladder: 31 nTPM

Single-cell type

  • enterocytes: 1,916 nCPM
  • foveolar cells: 1,067 nCPM
  • hepatocytes: 1,064 nCPM
  • urothelial cells: 675 nCPM
  • cholangiocytes: 647 nCPM
  • colonocytes: 614 nCPM

Immune cell

  • MAIT T-cell: 0.9 nTPM
  • memory CD4 T-cell: 0.6 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • naive CD8 T-cell: 0.5 nTPM
  • neutrophil: 0.5 nTPM
  • T-reg: 0.5 nTPM

Brain region

  • cerebral cortex: 6.3 nTPM
  • cerebellum: 6.2 nTPM
  • white matter: 5.6 nTPM
  • medulla oblongata: 5.5 nTPM
  • pons: 5.5 nTPM
  • choroid plexus: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.39
gnomAD pLI
0
gnomAD missense Z
1.17
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYP3A5 as an antibody target. Whether an autoantibody or antibody against CYP3A5 could matter depends on whether native CYP3A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYP3A5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYP3A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CYP3A5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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