Seroatlas · Human Serome Atlas

CYP27C1

Cytochrome P450 27C1

Also known as: C27C1_HUMAN, FLJ16008

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q4G0S4
Gene
CYP27C1
Ensembl
ENSG00000186684
Chromosome
2
Canonical length
542 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

542 residues, UniProt reviewed canonical sequence.

>Q4G0S4|CYP27C1
     1  MQTSAMALLA RILRAGLRPA PERGGLLGGG APRRPQPAGA RLPAGARAED KGAGRPGSPP
    61  GGGRAEGPRS LAAMPGPRTL ANLAEFFCRD GFSRIHEIQQ KHTREYGKIF KSHFGPQFVV
   121  SIADRDMVAQ VLRAEGAAPQ RANMESWREY RDLRGRATGL ISAEGEQWLK MRSVLRQRIL
   181  KPKDVAIYSG EVNQVIADLI KRIYLLRSQA EDGETVTNVN DLFFKYSMEG VATILYESRL
   241  GCLENSIPQL TVEYIEALEL MFSMFKTSMY AGAIPRWLRP FIPKPWREFC RSWDGLFKFS
   301  QIHVDNKLRD IQYQMDRGRR VSGGLLTYLF LSQALTLQEI YANVTEMLLA GVDTTSFTLS
   361  WTVYLLARHP EVQQTVYREI VKNLGERHVP TAADVPKVPL VRALLKETLR LFPVLPGNGR
   421  VTQEDLVIGG YLIPKGTQLA LCHYATSYQD ENFPRAKEFR PERWLRKGDL DRVDNFGSIP
   481  FGHGVRSCIG RRIAELEIHL VVIQLLQHFE IKTSSQTNAV HAKTHGLLTP GGPIHVRFVN
   541  RK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYP27C1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
4.8 nTPM

Expression across tissuesHPA

Tissue

  • skin: 4.8 nTPM
  • cervix: 2.4 nTPM
  • vagina: 2.3 nTPM
  • urinary bladder: 1.7 nTPM
  • esophagus: 1.4 nTPM
  • midbrain: 1.2 nTPM

Single-cell type

  • schwann cells: 42 nCPM
  • breast lactating cells: 34 nCPM
  • ocular epithelial cells: 20 nCPM
  • urothelial cells: 16 nCPM
  • prostatic hillock cells: 16 nCPM
  • papillary tip epithelial cells: 14 nCPM

Immune cell

  • basophil: 0.5 nTPM
  • neutrophil: 0.4 nTPM
  • gdT-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • thalamus: 9.1 nTPM
  • midbrain: 8.3 nTPM
  • amygdala: 4.9 nTPM
  • cerebellum: 4.9 nTPM
  • white matter: 4.7 nTPM
  • medulla oblongata: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
0.68
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYP27C1 as an antibody target. Whether an autoantibody or antibody against CYP27C1 could matter depends on whether native CYP27C1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYP27C1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYP27C1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CYP27C1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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