Seroatlas · Human Serome Atlas

CYP20A1

Cytochrome P450 20A1

Also known as: CP20A_HUMAN, CYP-M

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UW02
Gene: CYP20A1
Ensembl: ENSG00000119004
Chromosome: 2
Canonical length: 462 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cell Junctions,Actin filaments

OverviewNCBI Gene

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

462 residues, UniProt reviewed canonical sequence.

>Q6UW02|CYP20A1
     1  MLDFAIFAVT FLLALVGAVL YLYPASRQAA GIPGITPTEE KDGNLPDIVN SGSLHEFLVN
    61  LHERYGPVVS FWFGRRLVVS LGTVDVLKQH INPNKTSDPF ETMLKSLLRY QSGGGSVSEN
   121  HMRKKLYENG VTDSLKSNFA LLLKLSEELL DKWLSYPETQ HVPLSQHMLG FAMKSVTQMV
   181  MGSTFEDDQE VIRFQKNHGT VWSEIGKGFL DGSLDKNMTR KKQYEDALMQ LESVLRNIIK
   241  ERKGRNFSQH IFIDSLVQGN LNDQQILEDS MIFSLASCII TAKLCTWAIC FLTTSEEVQK
   301  KLYEEINQVF GNGPVTPEKI EQLRYCQHVL CETVRTAKLT PVSAQLQDIE GKIDRFIIPR
   361  ETLVLYALGV VLQDPNTWPS PHKFDPDRFD DELVMKTFSS LGFSGTQECP ELRFAYMVTT
   421  VLLSVLVKRL HLLSVEGQVI ETKYELVTSS REEAWITVSK RY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYP20A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 4.6 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 4.6 nTPM
kidney: 4.2 nTPM
skin: 3.5 nTPM
ovary: 3.4 nTPM
lymph node: 3.3 nTPM
adrenal gland: 3 nTPM

Single-cell type

early primary spermatocytes: 207 nCPM
leydig cells: 189 nCPM
sertoli cells: 151 nCPM
granulosa cells: 148 nCPM
plasma cells: 144 nCPM
early spermatids: 138 nCPM

Immune cell

naive B-cell: 9.3 nTPM
T-reg: 7.7 nTPM
memory CD4 T-cell: 7.4 nTPM
plasmacytoid DC: 6.9 nTPM
MAIT T-cell: 6.2 nTPM
non-classical monocyte: 6 nTPM

Brain region

white matter: 17 nTPM
medulla oblongata: 16 nTPM
choroid plexus: 15 nTPM
basal ganglia: 15 nTPM
thalamus: 14 nTPM
cerebral cortex: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYP20A1 as an antibody target. Whether an autoantibody or antibody against CYP20A1 could matter depends on whether native CYP20A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYP20A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYP20A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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