Seroatlas · Human Serome Atlas

CYLC2

Cylicin-2

Also known as: CYLC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14093
Gene: CYLC2
Ensembl: ENSG00000155833
Chromosome: 9
Canonical length: 348 aa
Protein class: Predicted intracellular proteins
Subcellular location: Perinuclear theca,Calyx

OverviewNCBI Gene

Cylicin II (CYCL2) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>Q14093|CYLC2
     1  MSLPRFQRVN FGPYDNYIPV SELSKKSWNQ QHFALLFPKP QRPGTKRRSK PSQIRDNTVS
    61  IIDEEQLRGD RRQPLWMYRS LMRISERPSV YLAARRQPLK PTRTVEVDSK AAEIGKKGED
   121  KTTQKDTTDS ESELKQGKKD SKKGKDIEKG KEEKLDAKKD SKKGKKDAEK GKDSATESED
   181  EKGGAKKDNK KDKKDSNKGK DSATESEGEK GGTEKDSKKG KKDSKKGKDS AIELQAVKAD
   241  EKKDEDGKKD ANKGDESKDA KKDAKEIKKG KKDKKKPSST DSDSKDDVKK ESKKDATKDA
   301  KKVAKKDTEK ESADSKKDAK KNAKKDAKKD AKKNAKKDEK KDAKKKGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYLC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

testis: 44 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 3,728 nCPM
early spermatids: 2,414 nCPM
late primary spermatocytes: 909 nCPM
leydig cells: 7.7 nCPM
sertoli cells: 5.7 nCPM
peritubular myoid cells: 2.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 1.2 nTPM
cerebellum: 1.1 nTPM
cerebral cortex: 1.1 nTPM
medulla oblongata: 1.1 nTPM
pons: 1.1 nTPM
amygdala: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
gnomAD missense Z: -1.42
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of cytoskeleton

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYLC2 as an antibody target. Whether an autoantibody or antibody against CYLC2 could matter depends on whether native CYLC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYLC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYLC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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