CYCS

Protein identityUniProt · HPA

UniProt accession

P99999

Gene

CYCS

Ensembl

ENSG00000172115

Chromosome

7

Canonical length

105 aa

Protein class

Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

105 residues, UniProt reviewed canonical sequence.

>P99999|CYCS
     1  MGDVEKGKKI FIMKCSQCHT VEKGGKHKTG PNLHGLFGRK TGQAPGYSYT AANKNKGIIW
    61  GEDTLMEYLE NPKKYIPGTK MIFVGIKKKE ERADLIAYLK KATNE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYCS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

747 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CYCS.

Disease | AllUniProt

Conditions CYCS is implicated in, by any mechanism.

• Thrombocytopenia 4 (THC4) MIM:612004

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 59 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Thrombocytopenia 4
• Thrombocytopenia

ReferencesPubMed · IEDB

Publications for CYCS from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.91

gnomAD pLI

0.64

gnomAD missense Z

1.18

DepMap mean gene effect

-0.71

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic signaling pathway
• cellular respiration
• execution phase of apoptosis
• intrinsic apoptotic signaling pathway
• mitochondrial electron transport, cytochrome c to oxygen
• mitochondrial electron transport, ubiquinol to cytochrome c

Molecular functions

• electron transfer activity
• heme binding
• metal ion binding

Cellular components

• apoptosome
• cytosol
• mitochondrial inner membrane
• mitochondrial intermembrane space
• mitochondrion
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Cytochrome c-like domain superfamily
• Cytochrome c, class IA/ IB
• Cytochrome c-like domain
• Cytochrome c

KeywordsUniProt

• Acetylation
• Apoptosis
• Electron transport
• Heme
• Iron
• Metal-binding
• Mitochondrion
• Phosphoprotein
• Respiratory chain
• Transport

InteractionsUniProt · HPA

Protein binding partners of CYCS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• APAF1