Seroatlas · Human Serome Atlas

CYBRD1

Plasma membrane ascorbate-dependent reductase CYBRD1

Also known as: CYB561A2, CYBR1_HUMAN, DCYTB, FLJ23462, FRRS3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53TN4
Gene: CYBRD1
Ensembl: ENSG00000071967
Chromosome: 2
Canonical length: 286 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

286 residues, UniProt reviewed canonical sequence.

>Q53TN4|CYBRD1
     1  MAMEGYWRFL ALLGSALLVG FLSVIFALVW VLHYREGLGW DGSALEFNWH PVLMVTGFVF
    61  IQGIAIIVYR LPWTWKCSKL LMKSIHAGLN AVAAILAIIS VVAVFENHNV NNIANMYSLH
   121  SWVGLIAVIC YLLQLLSGFS VFLLPWAPLS LRAFLMPIHV YSGIVIFGTV IATALMGLTE
   181  KLIFSLRDPA YSTFPPEGVF VNTLGLLILV FGALIFWIVT RPQWKRPKEP NSTILHPNGG
   241  TEQGARGSMP AYSGNNMDKS DSELNSEVAA RKRNLALDEA GQRSTM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYBRD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 220 nTPM

Expression across tissuesHPA

Tissue

small intestine: 220 nTPM
thyroid gland: 217 nTPM
duodenum: 186 nTPM
blood vessel: 183 nTPM
adipose tissue: 164 nTPM
ovary: 162 nTPM

Single-cell type

enterocytes: 873 nCPM
fibroblasts: 337 nCPM
peritubular myoid cells: 264 nCPM
leydig cells: 252 nCPM
fibro-adipogenic progenitors: 164 nCPM
alveolar cells type 1: 158 nCPM

Immune cell

intermediate monocyte: 18 nTPM
classical monocyte: 17 nTPM
myeloid DC: 17 nTPM
non-classical monocyte: 14 nTPM
neutrophil: 9.8 nTPM
total PBMC: 7.5 nTPM

Brain region

hypothalamus: 81 nTPM
medulla oblongata: 80 nTPM
white matter: 71 nTPM
midbrain: 66 nTPM
basal ganglia: 64 nTPM
thalamus: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0.01
gnomAD missense Z: 0.59
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ascorbate homeostasis
intracellular iron ion homeostasis
multicellular organismal-level iron ion homeostasis
response to iron ion
reductive iron assimilation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYBRD1 as an antibody target. Whether an autoantibody or antibody against CYBRD1 could matter depends on whether native CYBRD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYBRD1 is annotated at the cell surface, where native CYBRD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CYBRD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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