Seroatlas · Human Serome Atlas

CYB5RL

NADH-cytochrome b5 reductase-like

Also known as: LOC606495, NB5R5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IPT4
Gene: CYB5RL
Ensembl: ENSG00000215883
Chromosome: 1
Canonical length: 315 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H. Predicted to be involved in bicarbonate transport. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q6IPT4|CYB5RL
     1  MMAEREEDDD TEEAWMQLRP TEPLPSQCCG SGCSPCVFDL YHRDLARWEA AQASKDRSLL
    61  RGPESQSCPS KLNPETFVAF CIIAMDRLTK DTYRVRFALP GNSQLGLRPG QHLILRGIVD
   121  DLEIQRAYTP ISPANAEGYF EVLIKCYQMG LMSRYVESWR VGDTAFWRGP FGDFFYKPNQ
   181  YGELLLLAAG TGLAPMVPIL QSITDNENDE TFVTLVGCFK TFESIYLKTF LQEQARFWNV
   241  RTFFVLSQES SSEQLPWSYQ EKTHFGHLGQ DLIKELVSCC RRKPFALVCG SAEFTKDIAR
   301  CLLCAGLTED SYFLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYB5RL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 3.9 nTPM
pancreas: 3.8 nTPM
skeletal muscle: 3.8 nTPM
pituitary gland: 3.3 nTPM
skin: 3.1 nTPM
parathyroid gland: 3 nTPM

Single-cell type

tuft cells: 12 nCPM
gastric chief cells: 4.4 nCPM
paneth cells: 3.9 nCPM
hofbauer cells: 3.4 nCPM
epididymal principal cells: 2.6 nCPM
differentiating spermatogonia: 2.5 nCPM

Immune cell

intermediate monocyte: 0.9 nTPM
basophil: 0.6 nTPM
NK-cell: 0.6 nTPM
neutrophil: 0.5 nTPM
classical monocyte: 0.4 nTPM
eosinophil: 0.4 nTPM

Brain region

choroid plexus: 6.5 nTPM
cerebral cortex: 5.9 nTPM
basal ganglia: 5.4 nTPM
amygdala: 5.2 nTPM
white matter: 5.2 nTPM
hippocampal formation: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: -0.23
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

bicarbonate transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYB5RL as an antibody target. Whether an autoantibody or antibody against CYB5RL could matter depends on whether native CYB5RL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYB5RL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYB5RL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...