Seroatlas · Human Serome Atlas

CXorf66

Uncharacterized protein CXorf66

Also known as: CX066_HUMAN, RP11-35F15.2, SGPX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JRM2
Gene: CXorf66
Ensembl: ENSG00000203933
Chromosome: X
Canonical length: 361 aa
Protein class: Predicted membrane proteins
Subcellular location: Perinuclear theca,Calyx,Mid piece,Principal piece,End piece,Annulus

OverviewNCBI Gene

The protein encoded by this gene is predicted to be a type I membrane protein, however, its exact function is not known. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q5JRM2|CXorf66
     1  MNLVICVLLL SIWKNNCMTT NQTNGSSTTG DKPVESMQTK LNYLRRNLLI LVGIIIMVFV
    61  FICFCYLHYN CLSDDASKAG MVKKKGIAAK SSKTSFSEAK TASQCSPETQ PMLSTADKSS
   121  DSSSPERASA QSSTEKLIRP SSLQKPSIPN SAGKLTRPSY PKRSSKSSCS KKLSKSSHLE
   181  KAHKKGSLEK LCKLDYACKL ASSDKPVRPP QLFKPLYSSH PQNEISPSKP FGPQELAKPP
   241  KHFNPKRSVS LGRAALLSNS ELAETCQPYK KKHLVAKTYR PLVNDISEAK EKNTQNLHVS
   301  SKVKSSSRSF RKLDSRNNAY GDHVNDSDTM KYYSEVDSDK VIIITCDRGY NQVTSEVTLN
   361  D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXorf66 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
liver: 0.5 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early spermatids: 135 nCPM
late primary spermatocytes: 96 nCPM
late spermatids: 16 nCPM
leydig cells: 0.5 nCPM
sertoli cells: 0.3 nCPM
cardiomyocytes: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0.03
gnomAD missense Z: 0.2
DepMap mean gene effect: 0.19
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Uncharacterized protein CXorf66

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXorf66 as an antibody target. Whether an autoantibody or antibody against CXorf66 could matter depends on whether native CXorf66 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXorf66 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CXorf66 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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