CXorf58
Uncharacterized protein CXorf58
Also known as: CX058_HUMAN, FLJ25444
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96LI9
- Gene
- CXorf58
- Ensembl
- ENSG00000165182
- Chromosome
- X
- Canonical length
- 332 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
No narrative summary is available for CXorf58 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
332 residues, UniProt reviewed canonical sequence.
>Q96LI9|CXorf58
1 MNRSSNVPRK GILKSGTRSL QKVRRVHFAN ARNARSLLSM LKDISAQIIQ RAWLSHTNKM
61 IFRLLKHAIC AAEFYVTHEI LKKVAPLEAK LIKDPTMQCK IRFRFRGETF PPFIVFKIFL
121 HTDGHGYKYF SGKNVLMPSS KAVDDACKLM GERKFHRIIM EDERIFPKSK VTDIMDVVTM
181 QDYVQYRSFF DEAPAFSGGR NNSWRKLNLE NIPRTMLMYD IVHYSESGVI SNRLRNEMKF
241 LLQRPVTQEI HKHQLRIVSE IRGPYLTVQP LYRPYKQQNQ VKFLGRRSKQ AQMKVEKMRK
301 VYLAKEKNTS EVTEPKTGPS GTKDNYHLHS IFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CXorf58 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 3.7 nTPM
Expression across tissuesHPA
Tissue
- testis: 3.7 nTPM
- fallopian tube: 0.4 nTPM
- retina: 0.4 nTPM
- skeletal muscle: 0.3 nTPM
- thyroid gland: 0.3 nTPM
- kidney: 0.2 nTPM
Single-cell type
- late primary spermatocytes: 42 nCPM
- early primary spermatocytes: 29 nCPM
- early spermatids: 21 nCPM
- undifferentiated spermatogonia: 11 nCPM
- differentiating spermatogonia: 11 nCPM
- hematopoietic stem cells: 9.7 nCPM
Immune cell
- T-reg: 0.3 nTPM
- MAIT T-cell: 0.2 nTPM
- memory CD4 T-cell: 0.2 nTPM
- intermediate monocyte: 0.1 nTPM
- memory CD8 T-cell: 0.1 nTPM
- naive CD4 T-cell: 0.1 nTPM
Brain region
- medulla oblongata: 0.7 nTPM
- choroid plexus: 0.6 nTPM
- midbrain: 0.6 nTPM
- spinal cord: 0.6 nTPM
- cerebellum: 0.5 nTPM
- hypothalamus: 0.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.41
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.4
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CXorf58 as an antibody target. Whether an autoantibody or antibody against CXorf58 could matter depends on whether native CXorf58 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CXorf58 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CXorf58 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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