Seroatlas · Human Serome Atlas

CXorf51A

Uncharacterized protein CXorf51A

Also known as: CX05A_HUMAN, CXorf51

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTR3
Gene
CXorf51A
Ensembl
ENSG00000224440
Chromosome
X
Canonical length
108 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CXorf51A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>A0A1B0GTR3|CXorf51A
     1  MAKVTSEPQK PNEDVDEQTP STSSTKGRKK GKTPRQRRSR SGVKGLKTTR KAKRPLRGSS
    61  SQKAGETNTP AGKPKKARGP ILRGRYHRLK EKMKKEEADK EQSETSVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXorf51A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • testis: 67 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • late spermatids: 0.8 nCPM
  • late primary spermatocytes: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXorf51A as an antibody target. Whether an autoantibody or antibody against CXorf51A could matter depends on whether native CXorf51A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXorf51A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CXorf51A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CXorf51A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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