Seroatlas · Human Serome Atlas

CXorf49

Uncharacterized protein CXorf49

Also known as: CX049_HUMAN, CXorf49B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MYA2
Gene
CXorf49
Ensembl
ENSG00000215115
Chromosome
X
Canonical length
514 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CXorf49 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>A8MYA2|CXorf49
     1  MSSPDKVSVC GAGFDLEGGK KAGSRTASPG APGAHSHGLD LGVPGSGDGK SESGFTDPEG
    61  FSFESESELI EQGRVVLWGR EGRPGTPVDD QGDVVDYSFY LADEPAAIVP PPSVQGHPFP
   121  EGAAAEGSAE NWADAEVGPS GRDVLGHSPG KWQQASAGRL HLCGPGPVRA WKNPERGSKS
   181  RWSLRVDPQQ PSAKGPTRLP THDSDSADES SDLPLMKVGI CRNEGSQAKP GSPKKRADTS
   241  RQASFHCKES YLPVPGRFLT SAPRGLTPVA ERPAVGELED SPQKKMQSRA WGKVEVRPSC
   301  SGAAAAGALP QGLSRRKMAG GKKSLGGASQ LALGRGFPAC GERLSAAPPE PATFPPFSGV
   361  RPQGMSKKPQ KPKHSSPGKK PAGRKTRESQ AAAREDNDPN RDEVPRAQLP THRPGLPRLS
   421  VRRGEFSSSD PNIRAPQLPG TSEPSAYSPG GLVPRRHAPS GNQQPPVHPP RPERQQQPPG
   481  AQGCPRCIWL QREIEDLTQQ LAAMQFLTDK FQDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXorf49 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.74
Highest tissue expression
2 nTPM

Expression across tissuesHPA

Tissue

  • testis: 2 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterized protein CXorf49
  • Domain of unknown function (DUF4641)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXorf49 as an antibody target. Whether an autoantibody or antibody against CXorf49 could matter depends on whether native CXorf49 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXorf49 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CXorf49 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CXorf49. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...