Seroatlas · Human Serome Atlas

CXorf38

Uncharacterized protein CXorf38

Also known as: CX038_HUMAN, MGC39350

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TB03
Gene: CXorf38
Ensembl: ENSG00000185753
Chromosome: X
Canonical length: 319 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

319 residues, UniProt reviewed canonical sequence.

>Q8TB03|CXorf38
     1  MVLSELAARL NCAEYKNWVK AGHCLLLLRS CLQGFVGREV LSFHRGLLAA APGLGPRAVC
    61  RGGSRCSPRA RQFQPQCQVC AEWKREILRH HVNRNGDVHW GNCRPGRWPV DAWEVAKAFM
   121  PRGLADKQGP EECDAVALLS LINSCDHFVV DRKKVTEVIK CRNEIMHSSE MKVSSTWLRD
   181  FQMKIQNFLN EFKNIPEIVA VYSRIEQLLT SDWAVHIPEE DQRDGCECEM GTYLSESQVN
   241  EIEMQLLKEK LQEIYLQAEE QEVLPEELSN RLEVVKEFLR NNEDLRNGLT EDMQKLDSLC
   301  LHQKLDSQEP GRQTPDRKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXorf38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

lymph node: 15 nTPM
spleen: 14 nTPM
tonsil: 13 nTPM
thymus: 12 nTPM
appendix: 11 nTPM
thyroid gland: 10 nTPM

Single-cell type

neutrophils: 56 nCPM
monocytes: 54 nCPM
breast lactating cells: 51 nCPM
hofbauer cells: 49 nCPM
neutrophil progenitors: 46 nCPM
nk-cells: 43 nCPM

Immune cell

non-classical monocyte: 25 nTPM
eosinophil: 22 nTPM
neutrophil: 20 nTPM
classical monocyte: 16 nTPM
intermediate monocyte: 16 nTPM
myeloid DC: 14 nTPM

Brain region

white matter: 14 nTPM
medulla oblongata: 13 nTPM
thalamus: 13 nTPM
pons: 12 nTPM
spinal cord: 12 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4559
Domain of unknown function (DUF4559)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXorf38 as an antibody target. Whether an autoantibody or antibody against CXorf38 could matter depends on whether native CXorf38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXorf38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CXorf38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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