Seroatlas · Human Serome Atlas

CXCR6

C-X-C chemokine receptor type 6

Also known as: BONZO, CD186, CXCR6_HUMAN, STRL33, TYMSTR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00574
Gene: CXCR6
Ensembl: ENSG00000172215
Chromosome: 3
Canonical length: 342 aa
Protein class: CD markers, G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>O00574|CXCR6
     1  MAEHDYHEDY GFSSFNDSSQ EEHQDFLQFS KVFLPCMYLV VFVCGLVGNS LVLVISIFYH
    61  KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWVFGQV MCKSLLGIYT INFYTSMLIL
   121  TCITVDRFIV VVKATKAYNQ QAKRMTWGKV TSLLIWVISL LVSLPQIIYG NVFNLDKLIC
   181  GYHDEAISTV VLATQMTLGF FLPLLTMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF
   241  LLTQMPFNLM KFIRSTHWEY YAMTSFHYTI MVTEAIAYLR ACLNPVLYAF VSLKFRKNFW
   301  KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXCR6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

lymph node: 16 nTPM
spleen: 13 nTPM
placenta: 10 nTPM
tonsil: 10 nTPM
skeletal muscle: 9.5 nTPM
small intestine: 9 nTPM

Single-cell type

extravillous trophoblasts: 113 nCPM
t-cells: 87 nCPM
cardiomyocytes: 51 nCPM
migrating cytotrophoblasts: 38 nCPM
nk-cells: 28 nCPM
innate lymphoid cells: 27 nCPM

Immune cell

MAIT T-cell: 447 nTPM
memory CD8 T-cell: 112 nTPM
gdT-cell: 93 nTPM
NK-cell: 90 nTPM
T-reg: 87 nTPM
memory CD4 T-cell: 27 nTPM

Brain region

medulla oblongata: 7.5 nTPM
white matter: 7.3 nTPM
spinal cord: 6.1 nTPM
pons: 5.7 nTPM
hypothalamus: 5.3 nTPM
basal ganglia: 5.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: 1.28
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXCR6 as an antibody target. Whether an autoantibody or antibody against CXCR6 could matter depends on whether native CXCR6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXCR6 is annotated at the cell surface, where native CXCR6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CXCR6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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