Seroatlas · Human Serome Atlas

CXCL9

C-X-C motif chemokine 9

Also known as: CMK, crg-10, CXCL9_HUMAN, Humig, MIG, SCYB9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q07325
Gene: CXCL9
Ensembl: ENSG00000138755
Chromosome: 4
Canonical length: 125 aa
Protein class: Cancer-related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded is thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Aug 2020]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>Q07325|CXCL9
     1  MKKSGVLFLL GIILLVLIGV QGTPVVRKGR CSCISTNQGT IHLQSLKDLK QFAPSPSCEK
    61  IEIIATLKNG VQTCLNPDSA DVKELIKKWE KQVSQKKKQK NGKKHQKKKV LKVRKSQRSR
   121  QKKTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXCL9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 290 nTPM

Expression across tissuesHPA

Tissue

lymph node: 290 nTPM
appendix: 61 nTPM
thymus: 31 nTPM
lung: 30 nTPM
spleen: 29 nTPM
tonsil: 29 nTPM

Single-cell type

cdc: 40 nCPM
cholangiocytes: 30 nCPM
macrophages: 26 nCPM
undifferentiated spermatogonia: 15 nCPM
pericytes: 10 nCPM
monocytes: 7.7 nCPM

Immune cell

non-classical monocyte: 0.6 nTPM
intermediate monocyte: 0.2 nTPM
classical monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

medulla oblongata: 3.8 nTPM
pons: 3.2 nTPM
choroid plexus: 0.5 nTPM
spinal cord: 0.5 nTPM
white matter: 0.5 nTPM
midbrain: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXCL9 as an antibody target. Whether an autoantibody or antibody against CXCL9 could matter depends on whether native CXCL9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXCL9 is annotated as secreted, so native CXCL9 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CXCL9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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