CXCL6
C-X-C motif chemokine 6
Also known as: CKA-3, CXCL6_HUMAN, GCP-2, SCYB6
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P80162
- Gene
- CXCL6
- Ensembl
- ENSG00000124875
- Chromosome
- 4
- Canonical length
- 114 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
The protein encoded by this gene is a member CXC chemokine family. The encoded protein is a chemotactic for neutrophil granulocytes and has antibacterial action against gram-negative and gram-positive bacteria. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Jun 2020]
Canonical amino-acid sequenceUniProt
114 residues, UniProt reviewed canonical sequence.
>P80162|CXCL6
1 MSLPSSRAAR VPGPSGSLCA LLALLLLLTP PGPLASAGPV SAVLTELRCT CLRVTLRVNP
61 KTIGKLQVFP AGPQCSKVEV VASLKNGKQV CLDPEAPFLK KVIQKILDSG NKKNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CXCL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 95 nTPM
Expression across tissuesHPA
Tissue
- spleen: 95 nTPM
- gallbladder: 34 nTPM
- urinary bladder: 25 nTPM
- appendix: 13 nTPM
- seminal vesicle: 10 nTPM
- small intestine: 9.7 nTPM
Single-cell type
- cholangiocytes: 329 nCPM
- respiratory secretory cells: 317 nCPM
- respiratory deuterosomal cells: 261 nCPM
- endometrial secretory cells: 160 nCPM
- prostatic club cells: 112 nCPM
- conjunctival goblet cells: 77 nCPM
Immune cell
- neutrophil: 10 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 9.7 nTPM
- choroid plexus: 4.9 nTPM
- thalamus: 1.7 nTPM
- basal ganglia: 1.3 nTPM
- hypothalamus: 1.1 nTPM
- pons: 1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.97
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.68
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- antibacterial innate immune response
- antimicrobial humoral immune response mediated by antimicrobial peptide
- cell-cell signaling
- cellular response to lipopolysaccharide
- chemokine-mediated signaling pathway
- chemotaxis
- inflammatory response
- leukocyte homeostasis
- neutrophil activation
- neutrophil chemotaxis
- regulation of chemokine production
- signal transduction
- regulation of neutrophil mediated killing of gram-negative bacterium
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CXCL6 as an antibody target. Whether an autoantibody or antibody against CXCL6 could matter depends on whether native CXCL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CXCL6 is annotated as secreted, so native CXCL6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label CXCL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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