Seroatlas · Human Serome Atlas

CXCL5

C-X-C motif chemokine 5

Also known as: CXCL5_HUMAN, ENA-78, SCYB5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P42830
Gene: CXCL5
Ensembl: ENSG00000163735
Chromosome: 4
Canonical length: 114 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>P42830|CXCL5
     1  MSLLSSRAAR VPGPSSSLCA LLVLLLLLTQ PGPIASAGPA AAVLRELRCV CLQTTQGVHP
    61  KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK KVIQKILDGG NKEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXCL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 56 nTPM
appendix: 34 nTPM
lung: 10 nTPM
stomach: 8 nTPM
urinary bladder: 7.9 nTPM
cervix: 7.3 nTPM

Single-cell type

platelets: 150 nCPM
monocytes: 102 nCPM
mucous neck cells: 68 nCPM
gastric progenitor cells: 58 nCPM
endometrial secretory cells: 56 nCPM
salivary acinar cells: 48 nCPM

Immune cell

total PBMC: 2 nTPM
neutrophil: 0.4 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 19 nTPM
thalamus: 12 nTPM
pons: 6.3 nTPM
hypothalamus: 5.1 nTPM
midbrain: 4 nTPM
amygdala: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXCL5 as an antibody target. Whether an autoantibody or antibody against CXCL5 could matter depends on whether native CXCL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXCL5 is annotated as secreted, so native CXCL5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CXCL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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