Seroatlas · Human Serome Atlas

CXCL3

C-X-C motif chemokine 3

Also known as: CINC-2b, CXCL3_HUMAN, GRO3, GROg, MIP-2b, SCYB3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P19876
Gene: CXCL3
Ensembl: ENSG00000163734
Chromosome: 4
Canonical length: 107 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

107 residues, UniProt reviewed canonical sequence.

>P19876|CXCL3
     1  MAHATLSAAP SNPRLLRVAL LLLLLVAASR RAAGASVVTE LRCQCLQTLQ GIHLKNIQSV
    61  NVRSPGPHCA QTEVIATLKN GKKACLNPAS PMVQKIIEKI LNKGSTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXCL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 20 nTPM
cervix: 19 nTPM
lung: 17 nTPM
bone marrow: 15 nTPM
urinary bladder: 15 nTPM
appendix: 14 nTPM

Single-cell type

monocytes: 1,378 nCPM
epididymal basal cells: 1,167 nCPM
cdc: 807 nCPM
macrophages: 638 nCPM
endometrial secretory cells: 474 nCPM
epididymal efferent duct absorptive cells: 468 nCPM

Immune cell

total PBMC: 0.4 nTPM
intermediate monocyte: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

thalamus: 5 nTPM
cerebral cortex: 4 nTPM
amygdala: 0.7 nTPM
hypothalamus: 0.6 nTPM
white matter: 0.6 nTPM
choroid plexus: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CXCL3.

Disease | ImmuneIEDB

Conditions an epitope on CXCL3 was assayed in.

type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -0.72
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

chemokine activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXCL3 as an antibody target. Whether an autoantibody or antibody against CXCL3 could matter depends on whether native CXCL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXCL3 is annotated as secreted, so native CXCL3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CXCL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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