CXCL2
C-X-C motif chemokine 2
Also known as: CINC-2a, CXCL2_HUMAN, GRO2, GROb, MGSA-b, MIP-2a, SCYB2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P19875
- Gene
- CXCL2
- Ensembl
- ENSG00000081041
- Chromosome
- 4
- Canonical length
- 107 aa
- Protein class
- Cancer-related genes, Plasma proteins, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
Canonical amino-acid sequenceUniProt
107 residues, UniProt reviewed canonical sequence.
>P19875|CXCL2
1 MARATLSAAP SNPRLLRVAL LLLLLVAASR RAAGAPLATE LRCQCLQTLQ GIHLKNIQSV
61 KVKSPGPHCA QTEVIATLKN GQKACLNPAS PMVKKIIEKM LKNGKSNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CXCL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 537 nTPM
Expression across tissuesHPA
Tissue
- liver: 537 nTPM
- adipose tissue: 103 nTPM
- lung: 101 nTPM
- pancreas: 99 nTPM
- bone marrow: 84 nTPM
- urinary bladder: 76 nTPM
Single-cell type
- epididymal basal cells: 4,367 nCPM
- epididymal efferent duct absorptive cells: 3,571 nCPM
- breast lactating cells: 2,403 nCPM
- breast secretory cells: 1,912 nCPM
- fallopian secretory cells: 1,779 nCPM
- monocytes: 1,421 nCPM
Immune cell
- intermediate monocyte: 1.1 nTPM
- non-classical monocyte: 1.1 nTPM
- classical monocyte: 0.1 nTPM
- neutrophil: 0.1 nTPM
- basophil: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- thalamus: 17 nTPM
- hypothalamus: 17 nTPM
- medulla oblongata: 8.4 nTPM
- cerebral cortex: 7.6 nTPM
- amygdala: 5.8 nTPM
- midbrain: 5.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.95
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.1
- DepMap mean gene effect
- -0.21
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CXCL2 as an antibody target. Whether an autoantibody or antibody against CXCL2 could matter depends on whether native CXCL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CXCL2 is annotated as secreted, so native CXCL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label CXCL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...