Seroatlas · Human Serome Atlas

CXCL17

C-X-C motif chemokine 17

Also known as: CXL17_HUMAN, Dcip1, DMC, UNQ473, VCC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXB2
Gene: CXCL17
Ensembl: ENSG00000189377
Chromosome: 19
Canonical length: 119 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

119 residues, UniProt reviewed canonical sequence.

>Q6UXB2|CXCL17
     1  MKVLISSLLL LLPLMLMSMV SSSLNPGVAR GHRDRGQASR RWLQEGGQEC ECKDWFLRAP
    61  RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS RACQQFLKQC QLRSFALPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXCL17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 338 nTPM

Expression across tissuesHPA

Tissue

stomach: 338 nTPM
salivary gland: 146 nTPM
lung: 140 nTPM
esophagus: 126 nTPM
urinary bladder: 44 nTPM
pancreas: 43 nTPM

Single-cell type

esophageal apical cells: 2,922 nCPM
gastric chief cells: 1,910 nCPM
respiratory secretory cells: 1,436 nCPM
conjunctival goblet cells: 1,283 nCPM
parietal cells: 1,114 nCPM
submucosal glandular cells: 945 nCPM

Immune cell

eosinophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1.8 nTPM
amygdala: 1.7 nTPM
cerebral cortex: 1.6 nTPM
basal ganglia: 1.4 nTPM
white matter: 1.4 nTPM
hippocampal formation: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

C-X-C motif chemokine 17
VEGF co-regulated chemokine 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXCL17 as an antibody target. Whether an autoantibody or antibody against CXCL17 could matter depends on whether native CXCL17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXCL17 is annotated as secreted, so native CXCL17 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CXCL17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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