Seroatlas · Human Serome Atlas

CXCL14

C-X-C motif chemokine 14

Also known as: BMAC, bolekine, BRAK, CXL14_HUMAN, Kec, KS1, MIP-2g, NJAC, SCYB14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95715
Gene: CXCL14
Ensembl: ENSG00000145824
Chromosome: 5
Canonical length: 111 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

111 residues, UniProt reviewed canonical sequence.

>O95715|CXCL14
     1  MSLLPRRAPP VSMRLLAAAL LLLLLALYTA RVDGSKCKCS RKGPKIRYSD VKKLEMKPKY
    61  PHCEEKMVII TTKSVSRYRG QEHCLHPKLQ STKRFIKWYN AWNEKRRVYE E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXCL14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 767 nTPM

Expression across tissuesHPA

Tissue

skin: 767 nTPM
adipose tissue: 359 nTPM
kidney: 322 nTPM
salivary gland: 290 nTPM
small intestine: 233 nTPM
breast: 226 nTPM

Single-cell type

breast myoepithelial cells: 3,978 nCPM
epididymal basal cells: 3,396 nCPM
basal keratinocytes: 3,040 nCPM
epididymal efferent duct absorptive cells: 2,856 nCPM
endometrial glandular cells: 2,011 nCPM
pituicytes/fscs: 1,723 nCPM

Immune cell

myeloid DC: 0.7 nTPM
neutrophil: 0.2 nTPM
basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 72 nTPM
thalamus: 65 nTPM
midbrain: 62 nTPM
basal ganglia: 48 nTPM
hippocampal formation: 41 nTPM
amygdala: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0.04
gnomAD missense Z: 0.69
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

chemokine activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXCL14 as an antibody target. Whether an autoantibody or antibody against CXCL14 could matter depends on whether native CXCL14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXCL14 is annotated as secreted, so native CXCL14 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CXCL14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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