CXCL13
C-X-C motif chemokine 13
Also known as: ANGIE, ANGIE2, BCA-1, BLC, BLR1L, CXL13_HUMAN, SCYB13
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O43927
- Gene
- CXCL13
- Ensembl
- ENSG00000156234
- Chromosome
- 4
- Canonical length
- 109 aa
- Protein class
- Cancer-related genes, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]
Canonical amino-acid sequenceUniProt
109 residues, UniProt reviewed canonical sequence.
>O43927|CXCL13
1 MKFISTSLLL MLLVSSLSPV QGVLEVYYTS LRCRCVQESS VFIPRRFIDR IQILPRGNGC
61 PRKEIIVWKK NKSIVCVDPQ AEWIQRMMEV LRKRSSSTLP VPVFKRKIPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CXCL13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 506 nTPM
Expression across tissuesHPA
Tissue
- lymph node: 506 nTPM
- tonsil: 428 nTPM
- spleen: 298 nTPM
- appendix: 124 nTPM
- stomach: 34 nTPM
- urinary bladder: 30 nTPM
Single-cell type
- breast hormone-responsive cells: 509 nCPM
- decidual stromal cells: 212 nCPM
- endometrial stromal cells: 76 nCPM
- t-cells: 25 nCPM
- hepatocytes: 25 nCPM
- platelets: 17 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 2.2 nTPM
- basal ganglia: 0.7 nTPM
- cerebellum: 0.7 nTPM
- spinal cord: 0.7 nTPM
- cerebral cortex: 0.4 nTPM
- white matter: 0.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.52
- gnomAD pLI
- 0.83
- gnomAD missense Z
- 0.58
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- antimicrobial humoral immune response mediated by antimicrobial peptide
- B cell chemotaxis
- cell surface receptor signaling pathway
- cell-cell signaling
- cellular response to lipopolysaccharide
- chemokine-mediated signaling pathway
- chronic inflammatory response
- defense response to bacterium
- germinal center formation
- immune response
- inflammatory response
- neutrophil chemotaxis
- positive regulation of cell-cell adhesion mediated by integrin
- positive regulation of cytosolic calcium ion concentration
- positive regulation of integrin activation
- positive regulation of T cell chemotaxis
- regulation of angiogenesis
- regulation of humoral immune response
- regulation of Rap protein signal transduction
- endothelial cell chemotaxis to fibroblast growth factor
- lymphocyte chemotaxis across high endothelial venule
- negative regulation of endothelial cell chemotaxis to fibroblast growth factor
Molecular functions
- CCR10 chemokine receptor binding
- chemokine activity
- CXCR chemokine receptor binding
- CXCR3 chemokine receptor binding
- fibroblast growth factor binding
- heparin binding
- receptor ligand activity
- CXCR5 chemokine receptor binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CXCL13 as an antibody target. Whether an autoantibody or antibody against CXCL13 could matter depends on whether native CXCL13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CXCL13 is annotated as secreted, so native CXCL13 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label CXCL13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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