Seroatlas · Human Serome Atlas

CWH43

PGAP2-interacting protein

Also known as: CWH43-C, FLJ21511, PG2IP_HUMAN, PGAP2IP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H720
Gene: CWH43
Ensembl: ENSG00000109182
Chromosome: 4
Canonical length: 699 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus,Plasma membrane

OverviewNCBI Gene

Predicted to be involved in GPI anchor biosynthetic process. Predicted to act upstream of or within several processes, including cerebrospinal fluid circulation; establishment of protein localization; and protein N-linked glycosylation. Predicted to be located in extracellular region and membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

699 residues, UniProt reviewed canonical sequence.

>Q9H720|CWH43
     1  MPSLWREILL ESLLGCVSWS LYHDLGPMIY YFPLQTLELT GLEGFSIAFL SPIFLTITPF
    61  WKLVNKKWML TLLRIITIGS IASFQAPNAK LRLMVLALGV SSSLIVQAVT WWSGSHLQRY
   121  LRIWGFILGQ IVLVVLRIWY TSLNPIWSYQ MSNKVILTLS AIATLDRIGT DGDCSKPEEK
   181  KTGEVATGMA SRPNWLLAGA AFGSLVFLTH WVFGEVSLVS RWAVSGHPHP GPDPNPFGGA
   241  VLLCLASGLM LPSCLWFRGT GLIWWVTGTA SAAGLLYLHT WAAAVSGCVF AIFTASMWPQ
   301  TLGHLINSGT NPGKTMTIAM IFYLLEIFFC AWCTAFKFVP GGVYARERSD VLLGTMMLII
   361  GLNMLFGPKK NLDLLLQTKN SSKVLFRKSE KYMKLFLWLL VGVGLLGLGL RHKAYERKLG
   421  KVAPTKEVSA AIWPFRFGYD NEGWSSLERS AHLLNETGAD FITILESDAS KPYMGNNDLT
   481  MWLGEKLGFY TDFGPSTRYH TWGIMALSRY PIVKSEHHLL PSPEGEIAPA ITLTVNISGK
   541  LVDFVVTHFG NHEDDLDRKL QAIAVSKLLK SSSNQVIFLG YITSAPGSRD YLQLTEHGNV
   601  KDIDSTDHDR WCEYIMYRGL IRLGYARISH AELSDSEIQM AKFRIPDDPT NYRDNQKVVI
   661  DHREVSEKIH FNPRFGSYKE GHNYENNHHF HMNTPKYFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CWH43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.2
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

prostate: 40 nTPM
skin: 24 nTPM
esophagus: 20 nTPM
colon: 16 nTPM
rectum: 15 nTPM
fallopian tube: 14 nTPM

Single-cell type

prostatic glandular cells: 237 nCPM
esophageal apical cells: 113 nCPM
endometrial ciliated cells: 83 nCPM
fallopian tube ciliated cells: 79 nCPM
esophageal suprabasal cells: 77 nCPM
renal connecting tubule cells: 74 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

spinal cord: 0.3 nTPM
thalamus: 0.3 nTPM
medulla oblongata: 0.2 nTPM
midbrain: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Endonuclease/exonuclease/phosphatase superfamily
GPI-anchor maturation lipid remodeler
PGAP2IP, second transmembrane domain
PGAP2IP, first transmembrane domain
PGAP2IP, C-terminal nuclease-like domain
PGAP2IP, second transmembrane domain
PGAP2IP, first transmembrane domain
PGAP2IP, C-terminal nuclease-like domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CWH43 as an antibody target. Whether an autoantibody or antibody against CWH43 could matter depends on whether native CWH43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CWH43 is annotated as secreted, so native CWH43 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CWH43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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