Seroatlas · Human Serome Atlas

CWC27

Spliceosome-associated protein CWC27 homolog

Also known as: CWC27_HUMAN, NY-CO-10, SDCCAG-10, SDCCAG10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UX04
Gene
CWC27
Ensembl
ENSG00000153015
Chromosome
5
Canonical length
472 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in nucleoplasm. Part of U2-type precatalytic spliceosome and catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>Q6UX04|CWC27
     1  MSNIYIQEPP TNGKVLLKTT AGDIDIELWS KEAPKACRNF IQLCLEAYYD NTIFHRVVPG
    61  FIVQGGDPTG TGSGGESIYG APFKDEFHSR LRFNRRGLVA MANAGSHDNG SQFFFTLGRA
   121  DELNNKHTIF GKVTGDTVYN MLRLSEVDID DDERPHNPHK IKSCEVLFNP FDDIIPREIK
   181  RLKKEKPEEE VKKLKPKGTK NFSLLSFGEE AEEEEEEVNR VSQSMKGKSK SSHDLLKDDP
   241  HLSSVPVVES EKGDAPDLVD DGEDESAEHD EYIDGDEKNL MRERIAKKLK KDTSANVKSA
   301  GEGEVEKKSV SRSEELRKEA RQLKRELLAA KQKKVENAAK QAEKRSEEEE APPDGAVAEY
   361  RREKQKYEAL RKQQSKKGTS REDQTLALLN QFKSKLTQAI AETPENDIPE TEVEDDEGWM
   421  SHVLQFEDKS RKVKDASMQD SDTFEIYDPR NPVNKRRREE SKKLMREKKE RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CWC27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 26 nTPM
  • skeletal muscle: 23 nTPM
  • bone marrow: 22 nTPM
  • thymus: 21 nTPM
  • heart muscle: 19 nTPM
  • ovary: 19 nTPM

Single-cell type

  • early spermatids: 412 nCPM
  • late primary spermatocytes: 204 nCPM
  • neutrophil progenitors: 154 nCPM
  • choroid plexus epithelial cells: 150 nCPM
  • oligodendrocyte progenitor cells: 145 nCPM
  • erythrocyte progenitors: 144 nCPM

Immune cell

  • NK-cell: 23 nTPM
  • basophil: 21 nTPM
  • MAIT T-cell: 21 nTPM
  • T-reg: 21 nTPM
  • memory B-cell: 20 nTPM
  • myeloid DC: 19 nTPM

Brain region

  • cerebellum: 53 nTPM
  • cerebral cortex: 44 nTPM
  • white matter: 43 nTPM
  • basal ganglia: 40 nTPM
  • hypothalamus: 39 nTPM
  • thalamus: 39 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CWC27.

Disease | AllUniProt

Conditions CWC27 is implicated in, by any mechanism.

  • Retinitis pigmentosa with or without skeletal anomalies (RPSKA) MIM:250410

Disease | GeneticClinVar

45 pathogenic / likely-pathogenic of 425 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.9
gnomAD pLI
0
gnomAD missense Z
0.76
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CWC27 as an antibody target. Whether an autoantibody or antibody against CWC27 could matter depends on whether native CWC27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CWC27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CWC27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CWC27. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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